Freedman Bruce M
Plastic Surgery Associates of Northern Virginia, McLean, Virginia, USA.
J Dermatolog Treat. 2009;20(2):82-7. doi: 10.1080/09546630802301818.
Microdermabrasion has been accepted as a reliable, non-invasive method for facial rejuvenation. Recently, there has been interest in combining this technique with other modalities to increase its efficacy. The purpose of this study was to determine whether the addition of an antioxidant-based serum enhanced the dermatologic changes seen following microdermabrasion.
Ten female volunteers, aged 38-52 years, underwent a series of six diamond tip crystal-free microdermabrasion facial treatments spaced 7-10 days apart. An antioxidant serum rich in polyphenols was pneumatically applied to half the face immediately after each microdermabrasion treatment. Skin biopsies and skin polyphenolic antioxidant levels, determined by Raman spectroscopy, were obtained prior to and after the study period. Investigator ratings for efficacy were analyzed after the study period and compared to baseline.
Compared with the skin treated with microdermabrasion only, the skin treated with microdermabrasion plus antioxidant demonstrated significantly increased epidermal and papillary dermal thickness, and increased fibroblast density (p < 0.01). There was increased hyalinization of the papillary dermis with newly deposited collagen fibers. Skin polyphenolic antioxidant levels increased 32% in the skin treated with the polyphenolic antioxidant serum after microdermabrasion (p < 0.01). Clinical efficacy variables were significantly more improved in the antioxidant group when compared to baseline (p < 0.01). These changes were supported clinically via digital photography.
The addition of a polyphenolic antioxidant serum to a facial microdermabrasion regimen enhanced the clinical and histological changes seen following microdermabrasion alone. This combination should strengthen the use of microdermabrasion as a non-invasive facial rejuvenation tool and support the role of topical antioxidants as anti-aging factors.
微晶磨皮术已被公认为一种可靠的非侵入性面部年轻化方法。最近，人们对将该技术与其他方法相结合以提高其疗效产生了兴趣。本研究的目的是确定添加基于抗氧化剂的血清是否能增强微晶磨皮术后所见的皮肤变化。
10名年龄在38 - 52岁的女性志愿者接受了一系列6次无钻石尖晶体的微晶磨皮面部治疗，每次治疗间隔7 - 10天。每次微晶磨皮治疗后，立即将富含多酚的抗氧化剂血清经气动方式涂抹于半侧面部。在研究期前后获取皮肤活检样本以及通过拉曼光谱法测定的皮肤多酚抗氧化剂水平。研究期结束后分析研究者对疗效的评分，并与基线进行比较。
与仅接受微晶磨皮治疗的皮肤相比，接受微晶磨皮加抗氧化剂治疗的皮肤显示表皮和乳头层真皮厚度显著增加，成纤维细胞密度增加（p < 0.01）。乳头层真皮出现透明化增加，并伴有新沉积的胶原纤维。微晶磨皮后用多酚抗氧化剂血清治疗的皮肤中，皮肤多酚抗氧化剂水平增加了32%（p < 0.01）。与基线相比，抗氧化剂组的临床疗效变量有显著改善（p < 0.01）。这些变化通过数码摄影在临床上得到了证实。
在面部微晶磨皮方案中添加多酚抗氧化剂血清可增强单独进行微晶磨皮术后所见的临床和组织学变化。这种联合应用应能加强微晶磨皮术作为非侵入性面部年轻化工具的应用，并支持局部抗氧化剂作为抗衰老因子的作用。
