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乐果对大鼠尿羟脯氨酸的毒性作用

Toxicity of dimethoate on urinary hydroxyproline in rats.

作者信息

Reddy P N, Raj G D, Dhar S C

机构信息

Biochemistry Laboratory, Central Leather Research Institute, Madras India.

出版信息

Indian J Exp Biol. 1992 Jun;30(6):541-2.

PMID:1506040
Abstract

The effect of the administration of three different concentrations (2.25, 1.13 and 0.56 mg/100 g body weight) of dimethoate on the urinary excretion of total, non dialysable and free hydroxyproline were studied in female albino rats. Compared to controls, the urine contents were significantly lower in higher concentration (2.25 mg/100 g body weight) of dimethoate treated rats. The results clearly indicate that the urine contents were not much affected in lower concentration (0.56 mg/100 g body weight) of dimethoate treated rats compared to the other concentrations (1.13 and 0.56 mg/100 g body weight) of dimethoate treated rats.

摘要

研究了三种不同浓度(2.25、1.13和0.56毫克/100克体重)的乐果对雌性白化大鼠尿中总羟脯氨酸、非透析性羟脯氨酸和游离羟脯氨酸排泄的影响。与对照组相比,乐果处理组中较高浓度(2.25毫克/100克体重)的大鼠尿液含量显著降低。结果清楚地表明,与乐果处理的其他浓度组(1.13和2.25毫克/100克体重)相比,乐果处理组中较低浓度(0.56毫克/100克体重)的大鼠尿液含量受影响不大。

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