Pilonchery G, Finck C, Minaire P, Messy P, Revol A
Ann Biol Clin (Paris). 1982;40(1):17-22.
Having established reference values for the different forms of urinary excretion of hydroxyproline on the basis of the results obtained in 12 normal subjects aged from 20 to 43 years, the authors studied the influence of three diets on the excretion of total, free and conjugated hydroxyproline. Urinary levels of total and peptide dialysable hydroxyprolines were found to be highly sensitive to the dietary collagen content, whilst free hydroxyproline increased only when the dietary collagen intake was very high. Peptide non-dialysable hydroxyproline, corresponding to peptides of molecular weight 6000-8000 was not influenced by diet. The ratio dialysable hydroxyproline/non-dialysable hydroxyproline varied from reference values if the diet was loaded with collagen. Only the ratio free hydroxyproline/non-dialysable hydroxyproline seemed to be independent of diet in the subjects studied.
基于对12名年龄在20至43岁的正常受试者所获结果，确定了羟脯氨酸不同形式的尿排泄参考值后，作者研究了三种饮食对总羟脯氨酸、游离羟脯氨酸和结合羟脯氨酸排泄的影响。发现尿中总羟脯氨酸和可透析肽羟脯氨酸水平对饮食中胶原蛋白含量高度敏感，而仅当饮食中胶原蛋白摄入量非常高时游离羟脯氨酸才会增加。对应分子量为6000 - 8000肽段的不可透析肽羟脯氨酸不受饮食影响。如果饮食中富含胶原蛋白，可透析羟脯氨酸/不可透析羟脯氨酸的比值会偏离参考值。在所研究的受试者中，似乎只有游离羟脯氨酸/不可透析羟脯氨酸的比值与饮食无关。
