神经氨酸酶引起的家兔皮肤坏死性病变
Dermatonecrotic lesions in rabbits caused by neuraminidase.
作者信息
Isupov I V, Sagheyeva O F, Adamov A K, Sayapina L V, Kovalenko N M, Lukyanova O I
机构信息
Department of Pathohistology, Russian State Antiplague Research Institute, Microbe, Saratov.
出版信息
Indian J Med Res. 1992 May;95:152-6.
In an attempt to study the role of neuraminidase in cholera vibrio pathogenesis, the dermatonecrotic effect of a purified neuraminidase preparation was studied in rabbits. The experiments demonstrated that dermatonecrotic lesions resulted from intracutaneous injection of a purified neuraminidase preparation (0.5 specific human dose or 1 NU) as well as significant doses of cholera toxoid containing the enzyme (4,12,18 specific human doses).
为了研究神经氨酸酶在霍乱弧菌发病机制中的作用，对一种纯化的神经氨酸酶制剂在兔体内的皮肤坏死作用进行了研究。实验表明，皮内注射纯化的神经氨酸酶制剂（0.5个特定人用剂量或1个酶活性单位）以及含有该酶的大量霍乱类毒素（4、12、18个特定人用剂量）均会导致皮肤坏死病变。
Zotero 插件