Bhandare P N, Rataboli P V, Diniz D'Souza R S, Dhume V G
Department of Pharmacology, Goa Medical College, Tiswadi.
Indian J Physiol Pharmacol. 1992 Apr;36(2):130-2.
Endogenous nitric oxide has been proposed as one of the mediators of gastric cytoprotection. We studied the effect of the vasodilator hydralazine which acts via nitric oxide and thus is expected to have a gastroprotective action. However, hydralazine aggravates ethanol-induced gastric lesions. This effect is not influenced by pretreatment with the selective alpha 1 adrenergic antagonist prazosin but is abolished by the angiotensin converting enzyme inhibitor, captopril suggesting the involvement of the renin-angiotensin system.
内源性一氧化氮已被认为是胃细胞保护的介质之一。我们研究了通过一氧化氮起作用的血管扩张剂肼屈嗪的作用，因此预期它具有胃保护作用。然而，肼屈嗪会加重乙醇诱导的胃损伤。这种作用不受选择性α1肾上腺素能拮抗剂哌唑嗪预处理的影响，但可被血管紧张素转换酶抑制剂卡托普利消除，这表明肾素-血管紧张素系统参与其中。
