Rataboli P V, Bhandare P N, D'Souza R S, Dhume V G
Department of Pharmacology, Goa Medical College, Tiswadi.
Indian J Physiol Pharmacol. 1992 Jan;36(1):35-8.
The non-selective beta-adrenoceptor antagonist, propranolol, has been reported to protect against gastric injury in mice, an effect only partly due to prostaglandin release. This study was designed to confirm the gastric cytoprotective effect of propranolol in another species of animal, the rat, and investigate further its mechanism of action. Our results show that propranolol prevents both ethanol-induced gastric lesions as well as ethanol-induced contraction of the circular muscle of rat fundic strip. The local anaesthetic, lignocaine also inhibited the effect of ethanol on circular muscle. However, timolol, another non-selective beta-adrenoceptor antagonist, failed to produce such an action. The effect of propranolol was abolished by the cyclooxygenase inhibitor, indomethacin and a high dose of the guanylate cyclase inhibitor, methylene blue. The results suggest that in addition to prostaglandins, endogenous nitric oxide and the membrane stabilising action of propranolol may also be involved in its gastroprotective action.
据报道，非选择性β-肾上腺素能受体拮抗剂普萘洛尔可保护小鼠免受胃损伤，这种作用仅有部分是由于前列腺素释放所致。本研究旨在证实普萘洛尔在另一种动物即大鼠中的胃细胞保护作用，并进一步研究其作用机制。我们的结果表明，普萘洛尔既能预防乙醇诱导的胃损伤，也能预防乙醇诱导的大鼠胃底条环行肌收缩。局部麻醉药利多卡因也能抑制乙醇对环行肌的作用。然而，另一种非选择性β-肾上腺素能受体拮抗剂噻吗洛尔未能产生这种作用。普萘洛尔的作用可被环氧化酶抑制剂吲哚美辛和高剂量的鸟苷酸环化酶抑制剂亚甲蓝消除。结果表明，除前列腺素外，内源性一氧化氮和普萘洛尔的膜稳定作用也可能参与其胃保护作用。
