Nestel P, Nalubola R, Sivakaneshan R, Wickramasinghe A R, Atukorala S, Wickramanayake T
University of Peradeniya.
Int J Vitam Nutr Res. 2004 Jan;74(1):35-51. doi: 10.1024/0300-9831.74.1.35.
The use of flour fortified with 66 mg/kg of electrolytic or reduced iron to reduce the prevalence of anemia was determined in a two-year, double-blind, controlled trial. The trial was conducted in Sri Lanka among preschoolers between 9 and 71 months old, primary schoolers 6 to 11 years old, and nonpregnant women. At baseline, 18.4% of the preschoolers had low hemoglobin (Hb) concentrations. Neither electrolytic nor reduced iron had an effect on Hb concentration among preschoolers. Only 7% of the primary schoolers were anemic at the start of the trial and, again, fortification had no effect on Hb concentration. Twenty-nine percent of women had a low Hb at outset and there was no evidence that fortification had an effect on Hb in this group. The findings from this study suggest that fortification of flour with electrolytic iron or reduced iron was not beneficial in reducing anemia in this population. This was probably due to the low prevalence of anemia and low bioavailability of the fortificant iron. Fortification with either iron fortificant was acceptable.
在一项为期两年的双盲对照试验中,研究了使用每千克面粉添加66毫克电解铁或还原铁来降低贫血患病率的效果。该试验在斯里兰卡针对9至71个月大的学龄前儿童、6至11岁的小学生以及未怀孕的妇女开展。在基线时,18.4%的学龄前儿童血红蛋白(Hb)浓度较低。电解铁和还原铁对学龄前儿童的Hb浓度均无影响。在试验开始时,只有7%的小学生贫血,同样,强化对面粉的Hb浓度没有影响。29%的妇女在开始时Hb较低,且没有证据表明强化对面粉的Hb浓度有影响。这项研究的结果表明,用电解铁或还原铁强化面粉对降低该人群的贫血没有益处。这可能是由于贫血患病率低以及强化铁的生物利用率低。用任何一种铁强化剂进行强化都是可以接受的。