Vasin M V, Ushakov I B, Kovtun V Iu, Komarova S N, Semenova L A, Galkin A A
Institute of Military Medicine, Ministry of Deferense of Russian Federation, 126083 Russia.
Radiats Biol Radioecol. 2004 Jan-Feb;44(1):68-71.
In experiments on mice radioprotective properties of indraline, phenyleprine and melatonin were compared at topical application as an ointment at a place of local exposure of animal hind to a dose of 38.3 Gy of 60Co gamma-quanta. Factor of dose reduction was 1.27-1.32 for indraline (1-10% ointment) and 1.29 for phenyleprine (0.25% ointment). Antioxidants were low efficient at radiation skin burn. At later local radiation injuries, such as hind contracture, the efficiency of indraline was 1.33-1.5, that of phenyleprine was 1.28, and that of melatonine (2 and 5% ointment) was 1.23-1.47.
在对小鼠进行的实验中，将因屈林、去氧肾上腺素和褪黑素制成软膏局部应用于动物后肢局部暴露部位，使其接受38.3戈瑞的60Coγ射线剂量，比较它们的辐射防护特性。因屈林（1 - 10%软膏）的剂量降低系数为1.27 - 1.32，去氧肾上腺素（0.25%软膏）的剂量降低系数为1.29。抗氧化剂对放射性皮肤灼伤效果不佳。在后期的局部放射性损伤，如后肢挛缩方面，因屈林的效率为1.33 - 1.5，去氧肾上腺素为1.28，褪黑素（2%和5%软膏）为1.23 - 1.47。
