Vasin M M, Ushakov I B, Kovtun V Y
Vopr Onkol. 2016;62(3):406-12.
Experimental model of acute local radiation injuries (LRI) was the degree of radiation skin burns of mouse paws, observed through the 10 day within 1 month after local γ -60Co-irradiation at the doses of 20-45 Gy. For late local radiation injuries with a maximum of over 6 months after exposure to radiation, model was the contracture of animal paws and post-radiation amputation of limbs of the mouse. In the experiments on mice radioprotector indralin (B-190) IP as direct α1-adrenomimetic has a expressed protective effect on reducing acute and late LRI, equal in terms of dose reduction factor (DRF) 1.4 -1.5 that was comparable to their efficacy during radiation injuries of hematopoietic tissues. Indralin fully retain its radioprotective properties (DRF = 1.5-1.7) in the condition of repeated radioprotector administration through one day at total dose of 57 Gy (three times 19 Gy) of fractionated γ -irradiation. The protective effect of indralin improved at parenteral administration in the place of local irradiation. The local topical application of indralin in the ointments or in solution of dimethylsulfoxide has radioprotective effect, equal in the term of DRF to 1.3 -1.5 at acute and late LRI. Indralin also possessed a expressed radioprotective properties (DRF = 1.5) in decrease radiation injuries of salivary glands during local irradiation of head of rats.
急性局部辐射损伤（LRI）的实验模型是通过在局部γ-60Co照射剂量为20 - 45 Gy后的1个月内观察10天小鼠爪子的辐射皮肤烧伤程度来确定的。对于辐射后6个月以上的晚期局部辐射损伤，模型是动物爪子的挛缩以及小鼠肢体的辐射后截肢。在对小鼠的实验中，作为直接α1 - 肾上腺素能激动剂的辐射防护剂因屈林（B - 190）腹腔注射给药，对减轻急性和晚期LRI具有显著的保护作用，其剂量降低因子（DRF）为1.4 - 1.5，与在造血组织辐射损伤期间的功效相当。在分次γ照射总剂量为57 Gy（三次19 Gy）、每天重复给药一次辐射防护剂的情况下，因屈林完全保留其辐射防护特性（DRF = 1.5 - 1.7）。当在局部照射部位进行非肠道给药时，因屈林的保护作用增强。因屈林以软膏或二甲基亚砜溶液形式局部外用，在急性和晚期LRI时具有辐射防护作用，其DRF为1.3 - 1.5。在大鼠头部局部照射期间，因屈林在减轻唾液腺辐射损伤方面也具有显著的辐射防护特性（DRF = 1.5）。
