Gehlen H, Kroker K, Deegen E, Stadler P
Klinik für Pferde, Tierärztliche Hochschule Hannover.
Schweiz Arch Tierheilkd. 2004 Mar;146(3):119-26. doi: 10.1024/0036-7281.146.3.119.
30 warmblood horses were examined before and after sedation with 20 micrograms/kg BW detomidine, to determine changes of cardiac function parameters, using B-mode, M-mode and Doppler echocardiography. 15 horses showed a heart murmur, but no clinical signs of cardiac heart failure, 15 horses had neither a heart murmur nor other signs of cardiac disease. After sedation with detomidine we could recognise a significant increase of end-diastolic left atrium diameter, an increase of end-systolic left ventricular diameter and aortic root diameter. The end-systolic thickness of papillary muscle and interventricular septum showed a decrease. Fractional shortening and amplitude of left ventricular wall motion was decreased after sedation. The mitral valve echogram revealed a presystolic valve closure and an inflection in the Ac slope (B-notch) in xy horses before sedation. Both increased after sedation with detomidine. Doppler echocardiography showed a decrease of blood flow velocity and velocity time integral (VTI) in the left and right ventricular outflow tract after sedation. Regurgitant flow signals were intensified following sedation in xy horses, especially at the mitral valve.
对30匹温血马在静脉注射20微克/千克体重的地托咪定镇静前后进行检查，采用B型、M型和多普勒超声心动图来确定心功能参数的变化。15匹马出现心脏杂音，但无心力衰竭的临床症状，15匹马既无心脏杂音也无其他心脏疾病迹象。用地托咪定镇静后，我们可观察到舒张末期左心房内径显著增加，收缩末期左心室内径和主动脉根部内径增加。乳头肌和室间隔的收缩末期厚度减小。镇静后左心室壁运动的缩短分数和幅度降低。二尖瓣超声心动图显示，在镇静前xy匹马的二尖瓣在收缩前期关闭，Ac斜率（B切迹）有一个拐点。用地托咪定镇静后两者均增加。多普勒超声心动图显示，镇静后左、右心室流出道的血流速度和速度时间积分（VTI）降低。xy匹马在镇静后反流信号增强，尤其是二尖瓣处。
