Patteson M W, Gibbs C, Wotton P R, Cripps P J
Department of Clinical Veterinary Science, University of Bristol, Avon, UK.
Equine Vet J Suppl. 1995 Sep(19):33-7. doi: 10.1111/j.2042-3306.1995.tb04987.x.
Twenty-six horses were sedated with detomidine hydrochloride (Domosedan, SmithKline Beecham Animal Health, Tadworth, Surrey, UK) at a dose of 10 micrograms/kg bwt, administered i.v. Echocardiograms were recorded before and after sedation, measurements of cardiac dimensions were made and functional indices were calculated. The pre- and post sedation values were compared. No significant change was detected following sedation in the ejection time (ET), left ventricular dimension, left atrial diameter at the sinotubular junction at end-systole or end-diastole or at the sinus of Valsalva at end-diastole. Sedation was found to result in a statistically significant increase in end-systolic left ventricular diameter and internal area and aortic diameter measured at the sinus of Valsalva. Left ventricular free-wall thickness and interventricular septal thickness at end-systole, fractional shortening, fractional area change and heart rate were significantly reduced following sedation. A significant increase in pre-ejection period (PEP), duration of electromechanical systole (EMS) and PEP/ET (ejection time) was detected.
26匹马用盐酸右美托咪定（Domosedan，史克必成动物保健公司，英国萨里郡塔德沃思）以10微克/千克体重的剂量静脉注射进行镇静。在镇静前后记录超声心动图，测量心脏尺寸并计算功能指标。比较镇静前后的值。镇静后，射血时间（ET）、左心室尺寸、收缩末期或舒张末期窦管交界处的左心房直径或舒张末期主动脉窦的直径均未检测到显著变化。发现镇静导致收缩末期左心室直径、内部面积以及主动脉窦处测量的主动脉直径在统计学上显著增加。镇静后，收缩末期左心室游离壁厚度和室间隔厚度、缩短分数、面积变化分数和心率显著降低。检测到射血前期（PEP）、机电收缩期（EMS）持续时间和PEP/ET（射血时间）显著增加。
