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严重食物过敏反应:2002年过敏监测网络登记的107例病例。

Severe food anaphylaxis: 107 cases registered in 2002 by the Allergy Vigilance Network.

作者信息

Moneret-Vautrin D A, Kanny G, Morisset M, Rancé F, Fardeau M F, Beaudouin E

机构信息

Department of Internal Medicine, Clinical Immunology and Allergology, University Hospital, Avenue de Lattre de Tassigny, 54035 Nancy Cedex, France.

出版信息

Eur Ann Allergy Clin Immunol. 2004 Feb;36(2):46-51.

Abstract

BACKGROUND

The prevalence of food allergies increases, relating to diet modifications. The consumption of new foods--exotic foods or foods originally used for animal feed, new proteins, neo allergens due to the use of new technologies and soon, Genetically Modified Foods--are in the spotlight.

OBJECTIVE

It is essential to develop a system of food allergy vigilance encompassing the full range of foods being consumed. Understanding this imperative leads logically to the suggestion of developing an allergy vigilance network taking advantage of the ongoing experience of allergists "on the ground".

METHODS

The French Allergy Vigilance Network is subscribed to by 302 allergologists (267 of whom are French). The aims of the Network are to record cases of severe anaphylaxis, to establish an epidemiological data bank from prospective multicenter studies, and to monitor the allergic risk from novel foods.

RESULTS

In 2002, 107 cases of severe anaphylaxis were recorded: anaphylactic shock--59.8% (one fatal), systemic reaction--18.7%, laryngeal angio-edema--15.9%, acute severe asthma--5.6% (one fatal). The main allergens identified were peanuts, nuts, shellfish, lupine flour and wheat flour. Action has been taken as a result: information by industry on inadequate labeling, withdrawal of wrongly labeled batches, and university hospital centers have been encouraged to establish the allergenic safety of their catering services.

CONCLUSION

Setting up such a network in other countries would lead to a significant advance in knowledge of the peculiarities of allergies relating to a wide variety of eating habits.

摘要

背景

食物过敏的患病率呈上升趋势,这与饮食结构的改变有关。新型食物——异国食物或原本用作动物饲料的食物、新蛋白质、因新技术产生的新过敏原以及不久后出现的转基因食品——成为了关注焦点。

目的

建立一个涵盖所有食用食物的食物过敏监测系统至关重要。理解这一必要性自然会引出利用一线过敏症专科医生的现有经验建立过敏监测网络的建议。

方法

法国过敏监测网络有302名过敏症专科医生加入(其中267名是法国人)。该网络的目标是记录严重过敏反应病例,通过前瞻性多中心研究建立流行病学数据库,并监测新型食物的过敏风险。

结果

2002年,记录了107例严重过敏反应病例:过敏性休克——59.8%(1例死亡),全身反应——18.7%,喉部血管性水肿——15.9%,急性重症哮喘——5.6%(1例死亡)。确定的主要过敏原为花生、坚果、贝类、羽扇豆粉和小麦粉。因此采取了行动:行业提供标签不充分的信息,召回标签错误的批次,并且鼓励大学医院中心确定其餐饮服务的过敏原安全性。

结论

在其他国家建立这样一个网络将极大地推动对与各种饮食习惯相关的过敏特性的认识。

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