Zbanyszek M, Procajło A, Stopyra A, Sobiech P, Rajski K
Department of Internal Diseases, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 14, 10-957 Olsztyn, Poland.
Pol J Vet Sci. 2004;7(1):53-8.
Colic in horses very often induces changes in the coagulation system causing the development of disseminated intravascular clotting. It is promoted by blood concentration and an increase in exposition of coagulation activators with a simultaneous decrease in coagulation inhibitors activity, mainly antithrombin III. Progressing blood platelets aggregation supports production of microthromboses and plugging capillary vessels. The progression of this processes causes complications in basic disease and becomes the reason for therapeutic failure. Determination of coagulation system indexes such as the number of platelets, prothrombin time, activated partial thromboplastin time, thrombin time, concentration of fibrinogen and fibrinogen degradation products, and D-dimmer and antithrombin III contents enables diagnosis and facilitates appropriate therapy of colic in horses.
马的绞痛常常会引起凝血系统的变化，导致弥散性血管内凝血的发生。血液浓缩以及凝血激活剂暴露增加，同时凝血抑制剂活性降低，主要是抗凝血酶III活性降低，会促进这种情况的发生。不断进展的血小板聚集会促使微血栓形成并阻塞毛细血管。这个过程的进展会导致基础疾病出现并发症，并成为治疗失败的原因。测定凝血系统指标，如血小板数量、凝血酶原时间、活化部分凝血活酶时间、凝血酶时间、纤维蛋白原浓度和纤维蛋白原降解产物，以及D-二聚体和抗凝血酶III含量，有助于诊断马的绞痛并促进适当的治疗。
