来自阿根廷儿童的侵袭性肺炎链球菌分离株：血清型、肺炎球菌表面蛋白A（PspA）家族及遗传多样性。
Invasive Streptococcus pneumoniae isolates from Argentinian children: serotypes, families of pneumococcal surface protein A (PspA) and genetic diversity.
作者信息
Mollerach M, Regueira M, Bonofiglio L, Callejo R, Pace J, Di Fabio J L, Hollingshead S, Briles D
机构信息
Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junin 956, 1113 Buenos Aires, Argentina.
出版信息
Epidemiol Infect. 2004 Apr;132(2):177-84. doi: 10.1017/s0950268803001626.
Abstract
PspA is an antigenically variable virulence factor of Streptococcus pneumoniae that inhibits complement deposition and is a potential candidate for human vaccines. Of 64 published strains 96% are in PspA families 1 and 2; optimal protection is family-specific. Effective development of a PspA-containing vaccine requires more information about the PspA family of strains in parts of the world where the vaccine is most needed. In these studies we observed that of 149 isolates (of 19 capsular types) from Argentina, 54.4% were family 1, 41.6% were family 2 and 4.0% expressed both family 1 and family 2 PspAs. Box typing revealed the Argentinian strains to be from at least 10 clonally related groups.
摘要
肺炎球菌表面蛋白A（PspA）是肺炎链球菌的一种抗原性可变的毒力因子，可抑制补体沉积，是人类疫苗的潜在候选物。在已发表的64株菌株中，96%属于PspA家族1和2；最佳保护具有家族特异性。有效开发含PspA的疫苗需要更多关于世界上最需要该疫苗地区菌株的PspA家族的信息。在这些研究中，我们观察到，从阿根廷分离出的149株（19种荚膜型）菌株中，54.4%属于家族1，41.6%属于家族2，4.0%同时表达家族1和家族2的PspA。盒式分型显示，阿根廷菌株至少来自10个克隆相关组。
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