Jain Sudhir K, Agrawal S C, Jain P C
Department of Applied Microbiology, Cancer Hospital & Research Institute, Gwalior 474 009, India.
Hindustan Antibiot Bull. 2002 Feb-Nov;44(1-4):42-6.
The efficacy of four sulfadrugs i.e., sulfadiazine, sulfamethoxazole, sulfaguanidine and sulfamoxole were taken in different doses (500, 1000, 1500, 2000 and 2500 ppm) to test their effectiveness against five pathogenic organisms for the control of mycelial growth and sporulation. Amongst the drugs tested sulfamethoxazole seems to be most effective against most of the test fungi showing 96.78, 90.53, 86.62, 54.16 and 43.91 percent inhibition in mycelial growth of P. nigricans, A. flavus, A. corymbifera, A. niger and C. albicans, respectively at its 2500 ppm dose in the basal medium. Gradual reduction in sporulation in all the test organisms almost in all the sulfadrugs have caused inhibition in sporulation, in comparison to their respective controls. Maximum inhibitory effect of sulfadiazine was recorded in A. niger showing 77.26 percent inhibition in the mycelial growth at a dose of 2500 ppm. Sulfaguanidine at its higher dose i.e., 2500 ppm proved to be most toxic against A. corymbifera causing 56.39 percent inhibition in the mycelial growth, while the same dose could not be found much effective against other test fungi. Sulfamoxole was found to be quite effective against most of the test fungi causing 47.16 to 85.86 percent inhibition in the mycelial growth. A gradual inhibition in the vegetative growth and sporulation or budding in all the test fungi was noted by increasing the concentrations of the test sulfadrugs.
采用四种磺胺类药物，即磺胺嘧啶、磺胺甲恶唑、磺胺胍和磺胺异恶唑，以不同剂量（500、1000、1500、2000和2500 ppm）来测试它们对五种致病生物体控制菌丝生长和孢子形成的有效性。在所测试的药物中，磺胺甲恶唑似乎对大多数测试真菌最为有效，在基础培养基中其2500 ppm剂量下，对黑曲霉、黄曲霉、伞房曲霉、黑根霉和白色念珠菌的菌丝生长分别显示出96.78%、90.53%、86.62%、54.16%和43.91%的抑制率。与各自的对照相比，几乎所有磺胺类药物都使所有测试生物体的孢子形成逐渐减少，从而导致孢子形成受到抑制。磺胺嘧啶在黑根霉中记录到最大抑制作用，在2500 ppm剂量下菌丝生长抑制率为77.26%。磺胺胍在其较高剂量即2500 ppm时，对伞房曲霉毒性最大，导致菌丝生长抑制率为56.39%，而相同剂量对其他测试真菌的效果不太明显。磺胺异恶唑被发现对大多数测试真菌相当有效，导致菌丝生长抑制率为47.16%至85.86%。通过增加测试磺胺类药物的浓度，注意到所有测试真菌的营养生长以及孢子形成或出芽都逐渐受到抑制。
