Mensing H, Schallreuter K U, Senff H, Steinkraus V
Universitäts-Hautklinik Hamburg.
Hautarzt. 1992 Jul;43(7):436-40.
A retrospective study (1985-1989) of patients suffering from diffuse fasciitis with eosinophilia revealed that five of eight patients had taken L-tryptophan-containing drugs before the onset of the disease. In addition, since this drug-disease association was first described five patients have been diagnosed during the year 1990. All ten patients developed peripheral eosinophilia, myalgia and deep skin involvement indistinguishable from eosinophilic fasciitis. Corticosteroids were able to reduce the pain and inflammatory parameters, but did not prophylactically improve the long-standing sclerodermalike skin thickening. In 2/5 patients with symptoms longer than 1 year, low-dose corticosteroid maintenance therapy has been continuously required to control joint and muscle pain.
一项对嗜酸性粒细胞增多性弥漫性筋膜炎患者的回顾性研究（1985 - 1989年）显示，8名患者中有5名在疾病发作前服用了含L - 色氨酸的药物。此外，自这种药物与疾病的关联首次被描述以来，1990年又诊断出5名患者。所有10名患者均出现外周嗜酸性粒细胞增多、肌痛和深部皮肤受累，与嗜酸性筋膜炎难以区分。皮质类固醇能够减轻疼痛和炎症指标，但不能预防性改善长期存在的硬皮病样皮肤增厚。在症状持续超过1年的2/5患者中，一直需要低剂量皮质类固醇维持治疗来控制关节和肌肉疼痛。
