Iigo M, Nishikata K, Nakajima Y, Araki E
Chemotherapy Division, National Cancer Center Research Institute, Tokyo.
Jpn J Cancer Res. 1992 Apr;83(4):397-401. doi: 10.1111/j.1349-7006.1992.tb00121.x.
We investigated the responses of experimentally produced hepatic metastases of colon carcinoma 26 tumor and subcutaneously (SC) implanted colon carcinoma 26 tumor in mice to 17 clinically-used and one under-development antitumor agents using same dose regimen. In intravenous administrations on days 7 and 14, there were no significant differences in their responses to most of the tested agents. However, there were big differences in the responses to some of the agents. Nimustine more effectively prolonged the lifespan of SC implanted tumor-bearing mice than of mice bearing hepatic metastases. Mitomycin C was, however, considerably more effective on hepatic metastases than on SC implanted tumor. ME2303, a new fluorinated anthracycline derivative, showed a similar effect to doxorubicin on both tumors. However, administrations of ME2303 on days 7, 11 and 15 showed more marked antitumor effect only on hepatic metastases than administrations on days 7 and 14. Doxorubicin was less active against both tumors for administrations on days 7, 11 and 15 than for those on days 7 and 14. These results suggest the importance of the site of tumor growth for the action of some drugs. ME2303 may be active against hepatic metastases if it is administered by multiple injections.
我们使用相同的剂量方案，研究了实验性诱导产生的小鼠结肠癌26肝转移瘤以及皮下（SC）接种的结肠癌26肿瘤对17种临床常用抗肿瘤药物和1种正在研发的抗肿瘤药物的反应。在第7天和第14天进行静脉给药时，它们对大多数受试药物的反应没有显著差异。然而，对某些药物的反应存在很大差异。尼莫司汀比延长荷肝转移瘤小鼠的寿命更有效地延长了皮下接种荷瘤小鼠的寿命。然而，丝裂霉素C对肝转移瘤的疗效比对皮下接种肿瘤的疗效显著得多。新型氟化蒽环类衍生物ME2303对两种肿瘤的作用与阿霉素相似。然而，在第7、11和15天给予ME2303仅对肝转移瘤显示出比对在第7和14天给药更显著的抗肿瘤作用。在第7、11和15天给予阿霉素对两种肿瘤的活性比对在第7和14天给药时低。这些结果表明肿瘤生长部位对某些药物作用的重要性。如果通过多次注射给药，ME2303可能对肝转移瘤有活性。
