Wilson Andrew M, O'Neal David, Nelson Craig L, Prior David L, Best James D, Jenkins Alicia J
University of Melbourne, Department of Medicine, St. Vincent's Hospital, Melbourne, Australia.
Am J Hypertens. 2004 Apr;17(4):285-91. doi: 10.1016/j.amjhyper.2003.10.009.
An increasing number of arterial function assessments are available, including small and large arterial elasticity (SAE/C2, LAE/C1), endothelial function as measured by flow mediated dilation (FMD), carotid intima-medial thickness (IMT), ankle brachial index (ABI), pulse pressure (PP), and pulse wave velocity (PWV). We have consecutively performed these measures in subjects with low and high vascular disease risks to assess the interrelationships.
Twenty healthy subjects (HS) and 20 older subjects with type 2 diabetes mellitus (DM) were studied with all techniques at a single sitting by a single operator. In HS, C2 correlated with FMD (R = 0.577, P = .008), PWV (R = 0.522, P = .046), and ABI (R = 0.463, P = .04). There was no significant correlation of C1 and FMD or blood pressure (BP) measurements. In DM, C2 correlated with FMD (R = 0.443, P = .05), systolic BP (R = -0.553, P = .01), PP (R = -0.601, P = .005), and systemic vascular resistance (R = -0.577, P = .008). There was no significant correlation between anthropometric measures and arterial function measures in either group. The IMT was not correlated with any measure of arterial function in either group.
C2 assessed by pulse wave analysis correlated with endothelial function measured by FMD in young apparently healthy subjects and older subjects with type 2 diabetes. Systolic BP and PP correlated with C2 and FMD in older diabetic subjects but not healthy subjects. The interrelationships between arterial function measures are different in high and low risk populations. This variability needs to be considered when applying these techniques to individuals in different populations.
目前有越来越多的动脉功能评估方法，包括小动脉和大动脉弹性（SAE/C2、LAE/C1）、通过血流介导的血管舒张（FMD）测量的内皮功能、颈动脉内膜中层厚度（IMT）、踝臂指数（ABI）、脉压（PP）和脉搏波速度（PWV）。我们连续对血管疾病风险低和高的受试者进行这些测量，以评估它们之间的相互关系。
由一名操作人员在一次就诊时使用所有技术对20名健康受试者（HS）和20名老年2型糖尿病（DM）受试者进行了研究。在健康受试者中，C2与FMD（R = 0.577，P = 0.008）、PWV（R = 0.522，P = 0.046）和ABI（R = 0.463，P = 0.04）相关。C1与FMD或血压（BP）测量值之间无显著相关性。在糖尿病患者中，C2与FMD（R = 0.443，P = 0.05）、收缩压（R = -0.553，P = 0.01）、PP（R = -0.601，P = 0.005）和全身血管阻力（R = -0.577，P = 0.008）相关。两组中人体测量指标与动脉功能指标之间均无显著相关性。两组中IMT与任何动脉功能指标均无相关性。
通过脉搏波分析评估的C2与年轻健康受试者和老年2型糖尿病受试者中通过FMD测量的内皮功能相关。收缩压和PP在老年糖尿病受试者中与C2和FMD相关，但在健康受试者中不相关。动脉功能测量指标之间的相互关系在高风险和低风险人群中有所不同。将这些技术应用于不同人群的个体时需要考虑这种变异性。
