血浆中的转化生长因子-β1（TGF-β1）与患有全身炎症的秘鲁女性患先兆子痫的风险相关。
Transforming growth factor-beta1 (TGF-beta1) in plasma is associated with preeclampsia risk in Peruvian women with systemic inflammation.
作者信息
Muy-Rivera Martin, Sanchez Sixto E, Vadachkoria Surab, Qiu Chunfang, Bazul Victor, Williams Michelle A
机构信息
Center for Perinatal Studies, Swedish Medical Center, Seattle, Washington 98122, USA.
出版信息
Am J Hypertens. 2004 Apr;17(4):334-8. doi: 10.1016/j.amjhyper.2003.12.010.
BACKGROUND
In a case-control study of 100 preeclamptics and 100 controls, we assessed plasma transforming growth factor-beta1 (TGF-beta1) concentrations in relation to preeclampsia risk among Peruvian women with and without systemic inflammation.
METHODS
Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs).
RESULTS
The OR of preeclampsia increased across quartiles of TGF-beta1 concentrations. Women with elevated TGF-beta1 and a proinflammatory profile experienced the highest risk of preeclampsia (OR = 15.4, 95% CI 4.7-50.4).
CONCLUSIONS
Our results confirm an association between TGF-beta1 and risk of preeclampsia and extend the literature by indicating a strong association in women with systemic inflammation.
背景
在一项针对100例先兆子痫患者和100例对照的病例对照研究中，我们评估了秘鲁有或无全身炎症的女性血浆转化生长因子β1（TGF-β1）浓度与先兆子痫风险之间的关系。
方法
采用逻辑回归估计比值比（OR）和95%置信区间（CI）。
结果
先兆子痫的OR随着TGF-β1浓度四分位数的增加而升高。TGF-β1升高且具有促炎特征的女性患先兆子痫的风险最高（OR = 15.4，95% CI 4.7 - 50.4）。
结论
我们的结果证实了TGF-β1与先兆子痫风险之间的关联，并通过表明在全身炎症女性中存在强关联扩展了文献。
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