Department of Haemostatic Disorders, Medical University of Lodz, ul. Mazowiecka 6/8, 92-215 Lodz, Poland.
Int J Mol Sci. 2021 Apr 26;22(9):4492. doi: 10.3390/ijms22094492.
When treating diseases related primarily to tissue remodeling and fibrosis, it is desirable to regulate TGFβ concentration and modulate its biological effects. The highest cellular concentrations of TGFβ are found in platelets, with about 40% of all TGFβ found in peripheral blood plasma being secreted by them. Therefore, an understanding of the mechanisms of TGFβ secretion from platelets may be of key importance for medicine. Unfortunately, despite the finding that platelets are an important regulator of TGFβ levels, little research has been carried out into the development of platelet-directed therapies that might modulate the TGFβ-dependent processes. Nevertheless, there are some very encouraging reports suggesting that platelet TGFβ may be specifically involved in cardiovascular diseases, liver fibrosis, tumour metastasis, cerebral malaria and in the regulation of inflammatory cell functions. The purpose of this review is to briefly summarize these few, extremely encouraging reports to indicate the state of current knowledge in this topic. It also attempts to better characterize the influence of TGFβ on platelet activation and reactivity, and its shaping of the roles of blood platelets in haemostasis and thrombosis.
在治疗主要与组织重塑和纤维化相关的疾病时，调节 TGFβ 浓度并调节其生物学效应是理想的。TGFβ 的细胞内浓度最高的地方是血小板，外周血血浆中约有 40%的 TGFβ 是由它们分泌的。因此，了解血小板分泌 TGFβ 的机制对于医学可能至关重要。不幸的是，尽管已经发现血小板是 TGFβ 水平的重要调节剂，但对于开发可能调节 TGFβ 依赖性过程的针对血小板的治疗方法的研究很少。尽管如此，仍有一些非常令人鼓舞的报告表明血小板 TGFβ 可能特别参与心血管疾病、肝纤维化、肿瘤转移、脑疟疾以及炎症细胞功能的调节。本文的目的是简要总结这些为数不多的非常令人鼓舞的报告，以表明该主题的当前知识状态。它还试图更好地描述 TGFβ 对血小板激活和反应性的影响，以及其对血小板在止血和血栓形成中的作用的影响。
