Glesinger Ronen, Cohen Arnon D, Bogdanov-Berezovsky Alex, Krieger Yuval, Rosenberg Lior
Department of Plastic and Reconstructive Surgery and Burn Unit, Soroka University Medical Center, Beer-Sheva 84101, Israel.
Acad Emerg Med. 2004 Apr;11(4):339-42. doi: 10.1197/j.aem.2003.11.015.
Silver sulfadiazine 1% cream (SSD) and biafine (an oil-in-water emulsion containing alginate) are used for the treatment of superficial partial-thickness burns, but comparative effectiveness studies are lacking.
To compare the uses of SSD, Biafine (Labortoires Medix, Houdan, France), and saline-soaked gauze in the treatment of superficial partial-thickness burns in pigs.
This was a randomized controlled trial in four anesthetized young pigs. Four equal sets of partial-thickness contact burns were inflicted on the pigs. Each burn was randomly assigned to treatment with biafine, SSD, or saline-soaked gauze with dressing changes every other day. Assessment of wound re-epithelialization was performed every other day, for a total of two weeks. The treatment groups were compared by univariable and multivariable analyses of variance (ANOVAs), controlling for the pig and the location of the burns on each pig.
Thirty-two burns were inflicted on the pigs. Time to re-epithelialization of the burns was 13.5 days (SD +/- 0.9 days) in pigs treated with biafine, 13.3 days (+/-1.3 days) in pigs treated with SSD, and 13.5 days (+/-1.0 days) in pigs treated with saline-soaked gauze (p = not significant [NS]). The decreases in burn area from day 2 to day 12 were 21.4 cm(2) (+/-6.0 cm(2)) in pigs treated with biafine, 20.0 cm(2) (+/-6.3 cm(2)) in pigs treated with SSD, and 19.8 cm(2) (+/-5.9 cm(2)) in pigs treated with saline-soaked gauze (p = NS). A multivariable ANOVA showed a similar decrease in burn area between the treatment arms (p = NS) and a significant difference between the pigs (p = 0.015).
Partial-thickness porcine burns treated with SSD, biafine, and soaked saline gauze re-epithelialize at similar rates.
1%磺胺嘧啶银乳膏（SSD）和比亚芬（一种含藻酸盐的水包油乳液）用于治疗浅Ⅱ度烧伤，但缺乏对比有效性研究。
比较SSD、比亚芬（法国胡丹梅迪克斯实验室生产）和盐水浸湿纱布在猪浅Ⅱ度烧伤治疗中的应用。
这是一项在4只麻醉的幼猪身上进行的随机对照试验。在猪身上造成四组相等的浅Ⅱ度接触性烧伤。每次烧伤随机分配接受比亚芬、SSD或盐水浸湿纱布治疗，每隔一天更换敷料。每隔一天进行一次伤口再上皮化评估，共两周。通过单变量和多变量方差分析（ANOVA）对治疗组进行比较，同时控制猪以及每只猪身上烧伤的位置。
对猪造成了32处烧伤。用比亚芬治疗的猪烧伤再上皮化时间为13.5天（标准差±0.9天），用SSD治疗的猪为13.3天（±1.3天），用盐水浸湿纱布治疗的猪为13.5天（±1.0天）（p = 无显著差异[NS]）。从第2天到第12天，用比亚芬治疗的猪烧伤面积减少21.4平方厘米（±6.0平方厘米），用SSD治疗的猪减少20.0平方厘米（±6.3平方厘米），用盐水浸湿纱布治疗的猪减少19.8平方厘米（±5.9平方厘米）（p = NS）。多变量方差分析显示各治疗组之间烧伤面积减少情况相似（p = NS），猪之间存在显著差异（p = 0.015）。
用SSD、比亚芬和浸湿盐水纱布治疗的猪浅Ⅱ度烧伤，其再上皮化速率相似。
