Park Jong Min, Choe Yeon Hyeon, Chang Samuel, Sung Yon Mi, Kang Seok Seon, Kim Min Joo, Han Boo-Kyung, Choi Sang-Hee
Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Korean J Radiol. 2004 Jan-Mar;5(1):19-24. doi: 10.3348/kjr.2004.5.1.19.
To evaluate the usefulness of multidetector-row computed tomography(CT) in the evaluation of reperfused myocardial infarction.
Eleven rabbits were subjected to 90-min occlusion of the left anterior descending coronary artery followed by reperfusion. Multidetector-row CT was performed 31 hours+/-21 after the procedure and pre and post-contrast multiphase helical CT images were obtained up to 10 min after contrast injection. The animals were sacrificed after 30 days and histochemical staining of the resected specimens was performed with 2'3'5-triphenyl tetrazolium chloride (TTC).
In all 11 cases, the areas of myocardial infarction demonstrated with TTC-staining were identified on the CT images and the lesions showed hypoenhancement on the early phases up to 62 sec and hyperenhancement on the delayed phases of 5 min and 10 min compared with normal myocardial enhancement. The percentage area of the lesion with respect to the left ventricle wall on CT was significantly correlated with that of the TTC-staining results (p < 0.001 for both early and delayed phase CT) according to the generalized linear model analysis. The areas showing hypoenhancement on early CT were significantly smaller than those with hyperenhancement on delayed CT (p < 0.0001).
Multidetector-row CT may be useful in the detection and sizing of reperfused myocardial infarction.
评估多排螺旋计算机断层扫描（CT）在评价再灌注心肌梗死中的作用。
11只兔子接受左前降支冠状动脉90分钟闭塞后再灌注。在手术31小时±21小时后进行多排螺旋CT检查，在注射造影剂后10分钟内获取造影剂注射前和注射后的多期螺旋CT图像。30天后处死动物，用2,3,5-三苯基氯化四氮唑（TTC）对切除标本进行组织化学染色。
在所有11例中，TTC染色显示的心肌梗死区域在CT图像上均可识别，与正常心肌强化相比，病变在62秒内的早期阶段表现为强化减低，在5分钟和10分钟的延迟阶段表现为强化增加。根据广义线性模型分析，CT上病变面积相对于左心室壁的百分比与TTC染色结果显著相关（早期和延迟期CT均为p<0.001）。早期CT上强化减低区域明显小于延迟CT上强化增加区域（p<0.0001）。
多排螺旋CT在检测和测量再灌注心肌梗死方面可能有用。
