[Humoral factors (beta-endorphin and adrenocorticotropin) in irritable bowel syndrome and their relations with psychological disorders and characteristics of disorders in the large intestine motility].

The object of this study was to discover mental functions, humoral regulation and large intestinal motor dysfunction in patients with the irritable bowels syndrome (IBS) in order to develop principles of their differential correction. A group of 106 patients (26 men and 80 women) with the irritable bowels syndrome was examined. The IBS diagnosis was made in accordance with the Rome criteria (1999). The control group included 21 somatically healthy volunteers (16 women and 5 men). Patients from both of the groups underwent clinical and psychological as well as plasma beta-endorphin concentration studies; colonic motor activity was also studied in patients with the IBS by the method of electric colonoscopy. Mental changes and certain particular features of the large intestine humoral regulation and motor activity determining the differential treatment for this category of patients were discovered.