Embers Monica E, Ramamoorthy Ramesh, Philipp Mario T
Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, LA 70433, USA.
Microbes Infect. 2004 Mar;6(3):312-8. doi: 10.1016/j.micinf.2003.11.014.
To fight, flee or hide are the imperatives of long-term survival by an infectious microbe. Active immune suppression, induction of immune tolerance, phase and antigenic variation, intracellular seclusion, and incursion into immune privileged sites are examples of survival strategies of persistent pathogens. Here we critically review the supporting evidence for possible stratagems utilized by Borrelia burgdorferi, the spirochete that causes Lyme disease, to persist in the mammalian host.
战斗、逃跑或隐藏是传染性微生物长期生存的必要条件。主动免疫抑制、诱导免疫耐受、阶段和抗原变异、细胞内隔离以及侵入免疫特权部位是持续性病原体生存策略的例子。在此，我们批判性地回顾了导致莱姆病的螺旋体——伯氏疏螺旋体在哺乳动物宿主中持续存在可能采用的策略的支持证据。
