Naik U P, Eckfeld K
University of Delaware, Department of Biological Sciences, Newark, DE 19716, USA.
J Biol Regul Homeost Agents. 2003 Oct-Dec;17(4):341-7.
Junctional adhesion molecule 1 (JAM-1) was the first of a family of related proteins (JAM family) to be discovered. Two proteins with structural and sequence similarities to JAM-1, named JAM-2 and JAM-3, have been identified more recently. JAM-1 is specifically localized at the tight junctions of epithelial and endothelial cells and is involved in the regulation of junctional integrity and permeability. This function is attributed to its ability to interact in a homophilic manner. JAM-1 can also bind in a heterophilic manner as it serves as a ligand for integrin LFA-1 (CD11a/CD18), and plays a key role in the process of leukocyte transmigration. In addition, JAM-1 is also a receptor for reovirus, and is a platelet receptor involved in platelet adhesion and antibody-induced platelet aggregation. Further study of the mechanism of JAM-1 action within these diverse systems may demonstrate that JAM-1 is a key player in many different cellular functions.
连接黏附分子1（JAM-1）是相关蛋白家族（JAM家族）中首个被发现的蛋白。最近又鉴定出了另外两种与JAM-1在结构和序列上具有相似性的蛋白，分别命名为JAM-2和JAM-3。JAM-1特异性定位于上皮细胞和内皮细胞的紧密连接处，参与连接完整性和通透性的调节。该功能归因于其以同源方式相互作用的能力。JAM-1还可以以异源方式结合，因为它作为整合素LFA-1（CD11a/CD18）的配体，在白细胞迁移过程中起关键作用。此外，JAM-1还是呼肠孤病毒的受体，并且是参与血小板黏附和抗体诱导的血小板聚集的血小板受体。对JAM-1在这些不同系统中的作用机制进行进一步研究可能会表明，JAM-1在许多不同的细胞功能中都是关键参与者。
