Choi Bernard, Majaron Boris, Nelson J Stuart
University of California, Beckman Laser Institute, Irvine, California 92612, USA.
J Biomed Opt. 2004 Mar-Apr;9(2):299-307. doi: 10.1117/1.1646173.
We report on development of an optical-thermal model to evaluate the use of pulsed photothermal radiometry (PPTR) for depth profiling of port wine stain (PWS) skin. In the model, digitized histology sections of a PWS biopsy were used as the input skin geometry. Laser induced temperature profiles were reconstructed from simulated PPTR signals by applying an iterative, non-negatively constrained conjugate gradient algorithm. Accuracy of the following PWS skin characteristics extracted from the reconstructed profiles was determined: (1) average epidermal thickness (z(epi)), (2) maximum epidermal temperature rise (DeltaT(epi,max)), (3) depth of PWS upper boundary (z(PWS)), and (4) depth of maximum PWS temperature rise (z(PWS,max)). Comparison of the actual and reconstructed profiles from PPTR data revealed a good match for all four PWS skin characteristics. Results of this study indicate that PPTR is a viable approach for depth profiling of PWS skin.
我们报告了一种光热模型的开发情况，该模型用于评估脉冲光热辐射测量法（PPTR）在葡萄酒色斑（PWS）皮肤深度剖析中的应用。在该模型中，PWS活检的数字化组织学切片被用作输入的皮肤几何结构。通过应用迭代、非负约束共轭梯度算法，从模拟的PPTR信号中重建激光诱导的温度分布。确定了从重建分布中提取的以下PWS皮肤特征的准确性：（1）平均表皮厚度（z(epi)），（2）最大表皮温度升高（DeltaT(epi,max)），（3）PWS上边界深度（z(PWS)），以及（4）PWS最大温度升高深度（z(PWS,max)）。PPTR数据的实际分布与重建分布的比较表明，所有四个PWS皮肤特征都匹配良好。本研究结果表明，PPTR是PWS皮肤深度剖析的一种可行方法。
