Yang Bruce, Yang Owen, Guzman John, Nguyen Paul, Crouzet Christian, Osann Kathryn E, Kelly Kristen M, Nelson J Stuart, Choi Bernard
Beckman Laser Institute and Medical Clinic, University of California, Irvine, California 92612.
Department of Biomedical Engineering, University of California, Irvine, California 92697.
Lasers Surg Med. 2015 Aug;47(6):469-75. doi: 10.1002/lsm.22369. Epub 2015 Jun 3.
Port-wine stain (PWS) birthmarks affect ∼22 million people worldwide. After several treatment sessions, complete disappearance of the PWS occurs in only ∼10% of treated patients. There is a need to develop a new strategy to improve the efficacy of each treatment session and the overall treatment outcome. The study objective was to determine how intraoperative measurements of blood flow correlate with treatment response assessed several weeks post treatment.
STUDY DESIGN/MATERIALS AND METHODS: We employed Laser Speckle Imaging (LSI) to measure intraoperative blood-flow dynamics. We collected data from 24 subjects undergoing laser therapy for facial PWS birthmarks. Photographs were taken before treatment and at a follow-up visit, and analyzed by two expert observers.
Intraoperative LSI enables real-time monitoring of blood-flow dynamics in response to laser treatment and can inform clinicians on the need for focused re-treatment. The degree of PWS blanching achieved is positively correlated with the log-transformed acute blood-flow reduction (P = 0.022).
LSI is a simple, intraoperative monitoring tool during laser therapy of PWS birthmarks. LSI provides a single value for blood flow that correlates well with the degree of blanching achieved with laser therapy.
葡萄酒色斑（PWS）胎记影响着全球约2200万人。经过几次治疗后，只有约10%的接受治疗的患者的PWS完全消失。有必要开发一种新策略来提高每次治疗的效果和整体治疗结果。本研究的目的是确定术中血流测量与治疗后几周评估的治疗反应之间的相关性。
研究设计/材料与方法：我们采用激光散斑成像（LSI）来测量术中血流动力学。我们收集了24名接受面部PWS胎记激光治疗的受试者的数据。在治疗前和随访时拍摄照片，并由两名专家观察员进行分析。
术中LSI能够实时监测激光治疗后的血流动力学变化，并可为临床医生提供聚焦再治疗需求的信息。实现的PWS变白程度与对数转换后的急性血流减少呈正相关（P = 0.022）。
LSI是PWS胎记激光治疗期间一种简单的术中监测工具。LSI提供了一个与激光治疗实现的变白程度相关性良好的血流单一值。
