Weyant Robert J, Newman Anne B, Kritchevsky Stephen B, Bretz Walter A, Corby Patricia M, Ren Dianxu, Weissfeld Lisa, Rubin Susan M, Harris Tamara
Department of Dental Public Health, University of Pittsburgh, Pittsburgh, Pennsylvannia 15261, USA.
J Am Geriatr Soc. 2004 Apr;52(4):547-53. doi: 10.1111/j.1532-5415.2004.52160.x.
To determine the association between periodontal disease and weight loss in an elderly cohort.
A longitudinal design was used with participants from the Health, Aging and Body Composition (Health ABC) cohort study to determine the association between periodontal disease status and weight loss of at least 5% of baseline body weight over a period of 2 years.
Participants were examined in research clinics in Pittsburgh, Pennsylvania, and Memphis, Tennessee.
A randomly selected subset of 1,053 individuals from the Health ABC examination, aged 65 and older, ambulatory and community-dwelling at baseline.
Periodontal disease was measured as mean pocket depth and attachment loss, extent (percentage) of pockets with at least 6 mm probing depth, extent of bleeding on probing, and tissue inflammation.
In logistic regression models adjusting for variables that may explain weight loss, extent of periodontal pockets with at least 6 mm probing depth showed a significant association with weight loss (odds ratio=1.53, 95% confidence interval=1.32-1.77).
Periodontal disease may be causally related to weight loss in the elderly and thus may increase risk of morbidity and mortality.
确定老年队列中牙周疾病与体重减轻之间的关联。
采用纵向设计，研究对象来自健康、衰老和身体成分（Health ABC）队列研究，以确定牙周疾病状态与在2年时间内体重减轻至少基线体重5%之间的关联。
在宾夕法尼亚州匹兹堡和田纳西州孟菲斯的研究诊所对参与者进行检查。
从Health ABC检查中随机抽取的1053名65岁及以上的个体子集，基线时为非卧床且居住在社区。
牙周疾病通过平均牙周袋深度和附着丧失、至少6毫米探诊深度的牙周袋范围（百分比）、探诊出血范围和组织炎症来测量。
在对可能解释体重减轻的变量进行调整的逻辑回归模型中，至少6毫米探诊深度的牙周袋范围与体重减轻存在显著关联（比值比=1.53，95%置信区间=1.32-1.77）。
牙周疾病可能与老年人的体重减轻存在因果关系，因此可能增加发病和死亡风险。
