Bretz Walter A, Weyant Robert J, Corby Patricia M, Ren Dianxu, Weissfeld Lisa, Kritchevsky Stephen B, Harris Tamara, Kurella Manjula, Satterfield Suzanne, Visser Marjolein, Newman Anne B
Division of Pediatric and Developmental Science, University of Pittsburgh, PA 15261, USA.
J Am Geriatr Soc. 2005 Sep;53(9):1532-7. doi: 10.1111/j.1532-5415.2005.53468.x.
To study the levels of systemic markers for inflammation with parameters of periodontal diseases in older people.
A cross-sectional study was conducted in a cohort that is being followed prospectively on the effects of aging and body composition on morbidity.
University of Pittsburgh, Pittsburgh, and University of Tennessee, Memphis.
One thousand one hundred thirty-one participants (mean age+/-standard deviation 72.7+/-2.8); 66% white and 50% male.
Periodontal examination, including probing depth and attachment loss, was performed. Periodontal disease extent was divided into 0% of sites with probing depth of 6 mm or more, 1% to 10% of sites with probing depth of 6 mm or more and more than 10% of sites with probing depth of 6 mm or more. Subgingival plaque samples were collected from four molar teeth, and the levels of periodontal pathogens were determined using the benzoyl-DL-arginine-naphthylamide (BANA) test. Plasma interleukin-6 (IL-6), C-reactive protein (CRP), plasminogen activator inhibitor type-1 (PAI-1), and tumor necrosis factor alpha (TNF-alpha) levels were measured in all participants. Assessments of risk factors associated with elevated levels of markers of systemic inflammation were also determined. Multiple regression analysis was employed to analyze the data.
IL-6 levels were significantly higher in participants with more-extensive periodontal disease than in other participants. Periodontal disease extent was significantly associated with higher TNF-alpha plasma levels, controlling for established risk factors for elevated TNF-alpha levels. Participants with BANA-positive species had significantly higher CRP plasma levels when controlling for risk factors for elevated CRP levels.
Periodontal disease and infection may be modifiable risk indicators for elevated levels of systemic inflammatory markers in older people.
研究老年人炎症的全身标志物水平与牙周疾病参数之间的关系。
在一个前瞻性跟踪衰老和身体组成对发病率影响的队列中进行横断面研究。
匹兹堡大学（位于匹兹堡）和田纳西大学（位于孟菲斯）。
1131名参与者（平均年龄±标准差为72.7±2.8岁）；66%为白人，50%为男性。
进行牙周检查，包括探诊深度和附着丧失。牙周疾病范围分为探诊深度6毫米及以上的部位占0%、探诊深度6毫米及以上的部位占1%至10%以及探诊深度6毫米及以上的部位占10%以上。从四颗磨牙采集龈下菌斑样本，使用苯甲酰-DL-精氨酸萘酰胺（BANA）试验测定牙周病原体水平。测量所有参与者的血浆白细胞介素-6（IL-6）、C反应蛋白（CRP）、纤溶酶原激活物抑制剂1型（PAI-1）和肿瘤坏死因子α（TNF-α）水平。还确定了与全身炎症标志物水平升高相关的危险因素评估。采用多元回归分析对数据进行分析。
牙周疾病范围更广的参与者的IL-6水平显著高于其他参与者。在控制已确定的TNF-α水平升高的危险因素后，牙周疾病范围与较高的TNF-α血浆水平显著相关。在控制CRP水平升高的危险因素后，BANA阳性菌种的参与者的CRP血浆水平显著更高。
牙周疾病和感染可能是老年人全身炎症标志物水平升高的可改变风险指标。
