Giovagnoli D, Graham S J
Boulder Valley Eye Center, CO 80304.
J Am Optom Assoc. 1992 Jul;63(7):481-5.
Thirty subjects complaining of a decrease in soft contact lens wearing time secondary to dry eye discomfort were selected for our study. All subjects were between the ages of 25 and 40 and selected on the basis of subjective dry eye complaints alone. Five of these subjects had punctum that were too small to facilitate plug placement and were therefore eliminated from further study. Removable silicone punctal plugs were monocularly placed in the lower puncta of the remaining 25 subjects. In an attempt to minimize the placebo effect, both puncta were manipulated equally prior to plug insertion and the patient was not told which eye had been treated. Three weeks following plug placement, blind data assessment showed that 18 of the 25 subjects reported, on average, a 34.6 percent increase in comfortable contact lens wearing time in the treated eye. Three subjects reported no subjective increase in comfortable wearing time and four subjects were unable to tolerate the punctal plugs for more than a week due to plug-related discomfort. Problematic epiphora was not reported in any of the treated eyes. Reversible inferior punctal occlusion, when tolerated, can significantly increase comfortable contact lens wearing time while still allowing enough drainage from the upper puncta to prevent epiphora.
30名因干眼不适导致软性隐形眼镜佩戴时间减少的受试者被选入我们的研究。所有受试者年龄在25至40岁之间,仅根据主观干眼主诉入选。其中5名受试者的泪小点过小,不利于放置栓塞,因此被排除在进一步研究之外。可移除的硅胶泪小点栓塞被单眼放置在其余25名受试者的下泪小点中。为尽量减少安慰剂效应,在插入栓塞前,对双眼泪小点进行相同操作,且未告知患者哪只眼睛接受了治疗。栓塞放置三周后,盲态数据评估显示,25名受试者中有18名报告,治疗眼的舒适隐形眼镜佩戴时间平均增加了34.6%。3名受试者报告舒适佩戴时间无主观增加,4名受试者因栓塞相关不适无法耐受泪小点栓塞超过一周。任何一只治疗眼中均未报告有问题的溢泪情况。可逆性下泪小点阻塞在可耐受时,可显著增加舒适隐形眼镜佩戴时间,同时仍允许足够的泪液从上泪小点排出以防止溢泪。