Wang T F, Lee F Y, Tsai Y T, Lee S D, Wang S S, Hsia H C, Lin W J, Lin H C, Lai K H, Chan C Y
Department of Medicine, Veterans General Hospital, Taipei, Taiwan, Republic of China.
J Hepatol. 1992 May;15(1-2):170-3. doi: 10.1016/0168-8278(92)90031-j.
In a prospective study of 103 consecutive cirrhotic patients a high prevalence (43%) of anorectal varices was found compared with only 2% in 103 age- and sex-matched control subjects (p less than 0.001). However, there was no significant difference between the prevalences of hemorrhoids in cirrhotic patients and in control subjects (79% vs. 83%, p greater than 0.05). The hepatic venous pressure gradient of cirrhotic patients with anorectal varices was similar to cirrhotic patients without anorectal varices (14 +/- 6 mmHg, n = 22, vs. 16 +/- 7 mmHg, n = 39, p greater than 0.05. There was no significant difference in the hepatic venous pressure gradient between cirrhotic patients with and without hemorrhoids (15 +/- 6 mmHg, n = 47, vs. 16 +/- 8 mmHg, n = 14, p greater than 0.05). The prevalence of anorectal varices and hemorrhoids in cirrhotic patients had no relation to Child-Pugh's grading, esophageal varices with and without sclerotherapy and ascites. We conclude that anorectal varices are common in cirrhotic patients. Anorectal varices and hemorrhoids are not related to the degree of portal pressure.
在一项对103例连续肝硬化患者的前瞻性研究中,发现肛门直肠静脉曲张的患病率很高(43%),而在103例年龄和性别匹配的对照受试者中仅为2%(p<0.001)。然而,肝硬化患者和对照受试者中痔疮的患病率没有显著差异(79%对83%,p>0.05)。有肛门直肠静脉曲张的肝硬化患者的肝静脉压力梯度与没有肛门直肠静脉曲张的肝硬化患者相似(14±6 mmHg,n = 22,对16±7 mmHg,n = 39,p>0.05)。有痔疮和没有痔疮的肝硬化患者之间的肝静脉压力梯度没有显著差异(15±6 mmHg,n = 47,对16±8 mmHg,n = 14,p>0.05)。肝硬化患者中肛门直肠静脉曲张和痔疮的患病率与Child-Pugh分级、有无硬化治疗的食管静脉曲张及腹水无关。我们得出结论,肛门直肠静脉曲张在肝硬化患者中很常见。肛门直肠静脉曲张和痔疮与门静脉压力程度无关。