Tropeano Giovanna, Di Stasi Carmine, Litwicka Katarzyna, Romano Domenico, Draisci Gaetano, Mancuso Salvatore
Università Cattolica del Sacro Cuore, Rome, Italy.
Fertil Steril. 2004 Apr;81(4):1055-61. doi: 10.1016/j.fertnstert.2003.09.046.
To evaluate the impact of uterine artery embolization (UAE) for fibroids on ovarian reserve in women younger than 40 years.
Prospective study.
University-based reproductive endocrinology unit.
PATIENT(S): Twenty regularly cycling women aged 33-39 years undergoing UAE for fibroids. All had cycle day 3 FSH levels <10 mIU/mL.
INTERVENTION(S): Measurements of serum FSH and E2 levels and of the total ovarian volume and antral follicle number by transvaginal ultrasonography on day 3 of the menstrual cycle preceding UAE and on day 3 of the cycles occurring in months 3, 6, and 12 after UAE.
MAIN OUTCOME MEASURE(S): Preprocedural and postprocedural hormone levels, ovarian volumes, and antral follicle numbers.
RESULT(S): There were no significant changes from baseline in the mean day 3 FSH and E2 levels, ovarian volume measurements, and antral follicle numbers measured at 3, 6, and 12 months after UAE.
CONCLUSION(S): Although this study might be not sensitive enough to conclude that UAE for fibroids does not interfere with a woman's ovarian status, these data indicate that in this series of reproductive-aged women UAE did not have short- or mid-term effects on ovarian reserve as assessed by hormonal and sonographic parameters.
评估子宫肌瘤子宫动脉栓塞术（UAE）对40岁以下女性卵巢储备功能的影响。
前瞻性研究。
大学附属生殖内分泌科。
20名年龄在33 - 39岁、月经周期规律且因子宫肌瘤接受UAE治疗的女性。所有患者月经周期第3天的促卵泡生成素（FSH）水平均<10 mIU/mL。
在UAE术前月经周期第3天以及UAE术后3个月、6个月和12个月月经周期第3天，通过经阴道超声测量血清FSH和雌二醇（E2）水平、卵巢总体积和窦卵泡数量。
术前和术后的激素水平、卵巢体积和窦卵泡数量。
UAE术后3个月、6个月和12个月测量的月经周期第3天平均FSH和E2水平、卵巢体积测量值及窦卵泡数量与基线相比均无显著变化。
尽管本研究可能不够敏感，无法得出子宫肌瘤UAE术不会干扰女性卵巢状态的结论，但这些数据表明，在这一系列生育年龄女性中，根据激素和超声参数评估，UAE术对卵巢储备功能没有短期或中期影响。
