Breast Disease Research Center (BDRC), Tehran University of Medical Sciences, Tehran, Iran.
Department of Obstetrics and Gynecology, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran.
J Ovarian Res. 2023 Apr 6;16(1):68. doi: 10.1186/s13048-023-01149-7.
Ovarian reserve is a crucial indicator of a woman's fertility potential, which is determined by the quality and quantity of antral follicles and oocytes. However, certain factors such as endometriosis, pelvic inflammatory disease, myoma, and the natural process of aging can lead to a poor ovarian response to stimulation, reducing a woman's chances of conceiving.
To evaluate the effect of uterus congenital anomalies and uterine leiomyoma are associated on ovarian reserve.
The present cross-sectional study was performed on 321 infertile women in three groups consisted of 97 infertile women with intramural uterine leiomyoma and 81 infertile women with uterine anomalies and 143 infertile women without uterine anomalies and uterine leiomyoma during 2017-2019 in Royan Center. Sampling method was continuous and available. Data collection tool in this study was a questionnaire which was in two parts of individual variables and the second part was related to ultrasound results (number of antral follicles and ovarian volume) and laboratory tests (Anti-Mullerian Hormone (AMH) and Follicle-stimulating Hormone (FSH)). Ovarian reserve parameters were measured in three groups on the third day of the cycle in both groups. Data analysis was performed using SPSS software version 21. Quantitative variables were analyzed using t-test, qualitative variables were analyzed using chi-square test.
The results of in laboratory parameters showed that there was no statistically significant difference between the three groups in FSH (2.35 ± 1.55, 2.07 ± 1.81, 2.31 ± 1.93) and AMH (6.84 ± 2.75,7.52 ± 3.14,6.93 ± 3.04), respectively (P > 0.05). The results of sonographic variables also showed that the variables include number of antral follicles in right ovarian, number of antral follicles in left ovarian have statistically significant between the three groups (5.73 ± 2.69,4.84 ± 3.14,6.66 ± 3.13), respectively (P < 0.05).
The results of the present study showed that uterine abnormalities and uterine leiomyoma with different mechanisms such as reduce of antral follicle numbers and the effect on uterine and ovarian blood flow lead to a decrease in ovarian reserve and infertility. Therefore, treatment and surgery can reduce these effects and improve the fertility of the affected women.
卵巢储备是女性生育能力的一个重要指标，它由窦卵泡和卵母细胞的质量和数量决定。然而，某些因素，如子宫内膜异位症、盆腔炎、子宫肌瘤和自然衰老过程，会导致卵巢对刺激的反应不佳，降低女性怀孕的机会。
评估子宫先天畸形和子宫肌瘤与卵巢储备之间的关系。
本研究采用横断面研究方法，于 2017 年至 2019 年在罗扬中心纳入三组共 321 例不孕妇女，分别为 97 例患有壁间子宫肌瘤的不孕妇女、81 例患有子宫畸形的不孕妇女和 143 例无子宫畸形和子宫肌瘤的不孕妇女。采用连续、方便的抽样方法。本研究的数据收集工具是一份问卷，分为两部分：个人变量和第二部分与超声结果（窦卵泡数和卵巢体积）和实验室检查（抗苗勒管激素（AMH）和卵泡刺激素（FSH））相关。在两组的周期第 3 天测量三组的卵巢储备参数。使用 SPSS 软件版本 21 进行数据分析。定量变量采用 t 检验分析，定性变量采用卡方检验分析。
实验室参数结果显示，三组间 FSH（2.35±1.55、2.07±1.81、2.31±1.93）和 AMH（6.84±2.75、7.52±3.14、6.93±3.04）无统计学差异（P>0.05）。超声变量的结果也显示，右侧卵巢窦卵泡数、左侧卵巢窦卵泡数等变量在三组间有统计学差异（5.73±2.69、4.84±3.14、6.66±3.13）（P<0.05）。
本研究结果表明，子宫畸形和子宫肌瘤通过不同机制，如窦卵泡数量减少和对子宫及卵巢血流的影响，导致卵巢储备减少和不孕。因此，治疗和手术可以减少这些影响，提高受影响妇女的生育能力。
