Curcio Giuseppe, Ferrara Michele, Piergianni Assunta, Fratello Fabiana, De Gennaro Luigi
Laboratorio di Psicofisiologia del Sonno, Department of Psychology, University of Rome La Sapienza, Via dei Marsi 78, 00185 Rome, Italy.
Clin Neurophysiol. 2004 May;115(5):1178-88. doi: 10.1016/j.clinph.2003.12.018.
The first-night effect (FNE) is a common issue in sleep research. Being considered fragmented and poorly efficient, the adaptation night is discarded for data analysis. The present study aims to provide a quantitative and topographical EEG analysis of this phenomenon.
Eight healthy subjects slept for two consecutive nights (adaptation (AD) and baseline (BSL)), and their polysomnography was visually scored and then submitted to spectral power analysis.
The results showed a decreased quality and quantity of first-night sleep as indicated by more stage 1 and intrasleep wake, paralleled by a reduced sleep efficiency and a longer sleep onset latency. On the other hand, EEG quantitative data showed a more complex and apparently paradoxical picture. An increase in delta power was observed, particularly over the central areas during the first night, paralleled by an increased power in beta bin frequencies solely at posterior scalp locations.
These results have been interpreted as caused by, respectively, a reduced total sleep time during the adaptation night and a cortical hyperactivity, typical of psychophysiological insomnia. The present results confirm the need to exclude the laboratory sleep adaptation night from data analysis since it is not a reliable index of sleep on subsequent nights as regards both visual scoring and quantitative EEG analysis. Finally, regional differences between REM and NREM sleep have been confirmed.
This is the first attempt to evaluate the FNE with a quantitative approach to the antero-posterior EEG topography, providing both a Hz-by-Hz and a classical EEG band-based analysis.
首夜效应（FNE）是睡眠研究中的一个常见问题。由于适应夜被认为睡眠碎片化且效率低下，因此在数据分析时被舍弃。本研究旨在对这一现象进行定量和地形图脑电图分析。
8名健康受试者连续两晚睡眠（适应夜（AD）和基线夜（BSL）），对其多导睡眠图进行视觉评分，然后进行频谱功率分析。
结果显示，首夜睡眠的质量和数量下降，表现为更多的1期睡眠和睡眠中觉醒，同时睡眠效率降低，入睡潜伏期延长。另一方面，脑电图定量数据显示出更为复杂且明显矛盾的情况。观察到δ波功率增加，尤其是在首夜的中央区域，同时仅在后头皮位置的β频段频率功率增加。
这些结果分别被解释为适应夜总睡眠时间减少以及精神生理失眠典型的皮质多动所致。目前的结果证实，在数据分析中需要排除实验室睡眠适应夜，因为就视觉评分和脑电图定量分析而言，它都不是后续夜晚睡眠的可靠指标。最后，快速眼动睡眠和非快速眼动睡眠之间的区域差异得到了证实。
这是首次尝试采用定量方法对脑电图前后部地形图评估首夜效应，提供了逐赫兹和基于经典脑电图频段的分析。
