École de psychologie, Université Laval, Québec, Québec, Canada, G1V 0A6; Laboratoire de neurosciences comportementales humaines, Centre de recherche de l'Institut universitaire en santé mentale de Québec, 2525 de la Canardière, Québec (Québec), Canada, G1J 2G3.
Int J Psychophysiol. 2013 Aug;89(2):181-94. doi: 10.1016/j.ijpsycho.2013.06.004. Epub 2013 Jun 13.
The objectives of the study were to examine EEG activities using power spectral analysis (PSA) of good sleepers (GS), psychophysiological (PsyI) and paradoxical (ParI) insomnia sufferers on two consecutive nights. Participants completed three nights of PSG recordings in a sleep laboratory following a clinical evaluation. Participants were 26 PsyI, 20 ParI and 21 GS (mean age=40 years, SD=9.4). All sleep cycles of Nights 2 and 3 were retained for PSA. The absolute and relative activity in frequency bands (0.00 to 125.00 Hz) were computed at multiple frontal, central and parietal sites in REM and NREM sleep. Mixed model ANOVAs were performed with absolute and relative PSA data to assess differences between groups and nights. Over the course of the two nights, more absolute delta activity at F3, C3, and P3 was observed in ParI compared with PsyI suggesting deactivation of the left hemisphere in ParI and/or hyperactivation in PsyI. Further analysis on absolute PSA data revealed that differences between groups relate mostly to NREM. In REM, lower relative activity in slower frequency bands was found in ParI in comparison with GS and less relative theta activity was found in PsyI compared with GS implying higher activation in insomnia. In addition, between nights variability has been found in absolute powers of faster frequency bands (beta to omega). Signs of decreased cortical activity in absolute PSA in NREM combined with increased relative cortical activation in REM were found in ParI which might contribute to the misperception of sleep in ParI.
本研究旨在使用功率谱分析（PSA）检测优质睡眠者（GS）、心理生理性（PsyI）和矛盾性（ParI）失眠症患者的 EEG 活动，连续两晚进行研究。参与者在睡眠实验室进行了三晚的 PSG 记录，随后进行了临床评估。参与者包括 26 名 PsyI、20 名 ParI 和 21 名 GS（平均年龄为 40 岁，标准差为 9.4）。保留了第 2 天和第 3 天所有睡眠周期的 PSA。在 REM 和 NREM 睡眠中，在多个额、中央和顶部位点计算了频率带（0.00 至 125.00 Hz）的绝对和相对活动。使用绝对和相对 PSA 数据进行混合模型 ANOVA，以评估组间和夜间差异。在两个晚上的过程中，与 PsyI 相比，ParI 中 F3、C3 和 P3 的绝对 delta 活动更多，这表明 ParI 中左半球失活和/或 PsyI 中过度激活。对绝对 PSA 数据的进一步分析表明，组间差异主要与 NREM 相关。在 REM 中，与 GS 相比，ParI 中较慢频带的相对活动较低，与 GS 相比，PsyI 中相对 theta 活动较少，这表明失眠症患者的激活程度更高。此外，在绝对较快频带（β到ω）的功率方面发现了夜间变异性。在 NREM 中，ParI 中绝对 PSA 中发现皮质活动减少，而在 REM 中相对皮质激活增加，这可能导致 ParI 中对睡眠的错误感知。
