Silveira R, Stjernschantz J
Instituto de Investigaciones Biologicas, Clemente Estable, Division Neuroquimica, Montevideo, Uruguay.
J Ocul Pharmacol. 1992 Summer;8(2):129-37. doi: 10.1089/jop.1992.8.129.
The vascular effects of fasciculin and physostigmine, two acetylcholinesterase inhibitors, were studied with radioactively labelled microspheres in the rabbit eye. In addition, the effects on the intraocular pressure, pupil size and the aqueous humor protein concentration were determined. Both drugs were injected intracamerally in pentobarbital anesthetized and indomethacin pretreated animals. Fasciculin injected in a dose of 0.5 micrograms (0.7 x 10(-10)M) reduced blood flow in the anterior uvea as determined 30 and 60 min after injection. Higher doses had inconsistent effects. Physostigmine injected in a dose of 3 micrograms (1.1 x 10(-8)M) also reduced blood flow in the anterior uvea. The effect was most pronounced in the iris. Neither drug had any appreciable effect on choroidal or retinal blood flow. Both drugs caused pupillary constriction but the reduction in blood flow was not secondary to miosis. The effects on the intraocular pressure and aqueous humor protein concentration were inconsistent. The reduction in blood flow of the anterior uvea after intracameral injection of acetylcholinesterase inhibitors is consistent with a cholinergic vasoconstriction previously described in the eye during electrical stimulation of the oculomotor nerve.
在兔眼中，使用放射性标记微球研究了两种乙酰胆碱酯酶抑制剂束丝菌素和毒扁豆碱的血管效应。此外，还测定了它们对眼压、瞳孔大小和房水蛋白浓度的影响。两种药物均在戊巴比妥麻醉并经吲哚美辛预处理的动物眼内注射。注射0.5微克（0.7×10⁻¹⁰M）剂量的束丝菌素后30分钟和60分钟测定，其可减少前葡萄膜的血流。更高剂量的效果不一致。注射3微克（1.1×10⁻⁸M）剂量的毒扁豆碱也可减少前葡萄膜的血流。该效应在虹膜中最为明显。两种药物对脉络膜或视网膜血流均无明显影响。两种药物均引起瞳孔收缩，但血流减少并非继发于瞳孔缩小。它们对眼压和房水蛋白浓度的影响不一致。眼内注射乙酰胆碱酯酶抑制剂后前葡萄膜血流减少，这与先前在电刺激动眼神经时眼中描述的胆碱能血管收缩一致。
