Granstam E, Wang L, Bill A
Department of Physiology, Uppsala University, Sweden.
Curr Eye Res. 1992 Apr;11(4):325-32. doi: 10.3109/02713689209001786.
The effects of intravitreal and intracameral administration of endothelin-1 were studied in the anaesthetized cat. Intravitreal injection of 0.4 nmol endothelin-1 induced a 34 +/- 10% (n = 5; P less than 0.05) reduction in retinal blood flow in the experimental eye compared to the control eye 80 minutes after the injection. Blood flow in the ciliary body, iris and choroid remained unaffected by the injection of endothelin-1. Intracameral administration of endothelin-1 at pmol doses caused a reduction in pupil size, an increase in the aqueous humor protein concentration (indicating a break-down of the blood-aqueous barrier) and an increase in the concentration of prostaglandin E2 in the aqueous humor. The effect of endothelin-1 on pupil size was abolished by indomethacin pretreatment, indicating that this effect was mediated by arachidonic acid metabolites.
在麻醉猫身上研究了玻璃体内和前房内注射内皮素-1的效果。玻璃体内注射0.4 nmol内皮素-1后80分钟，与对照眼相比，实验眼的视网膜血流量减少了34±10%（n = 5；P<0.05）。睫状体、虹膜和脉络膜的血流量未受内皮素-1注射的影响。皮摩尔剂量的内皮素-1前房内给药导致瞳孔缩小、房水蛋白浓度升高（表明血-房水屏障破坏）以及房水中前列腺素E2浓度升高。吲哚美辛预处理消除了内皮素-1对瞳孔大小的影响，表明该作用是由花生四烯酸代谢产物介导的。
