Bruining Nico, Hamers Ronald, Teo Tat-Jin, de Feijter Pim J, Serruys Patrick W, Roelandt Jos R T C
Erasmus MC Rotterdam, Rotterdam, Netherlands.
Int J Cardiovasc Imaging. 2004 Apr;20(2):83-91. doi: 10.1023/b:caim.0000014046.63648.1c.
Intracoronary ultrasound (ICUS) is often used in studies evaluating new interventional techniques. It is important that quantitative measurements performed with various ICUS imaging equipment and materials are comparable. During evaluation of quantitative coronary ultrasound (QCU) software, it appeared that Boston Scientific Corporation (BSC) 30 MHz catheters connected to a Clearview ultrasound console showed smaller dimensions of an in vitro phantom model than expected. In cooperation with the manufacturer the cause of this underestimation was determined, which is described in this paper, and the QCU software was extended with an adjustment. Evaluation was performed by performing in vitro measurements on a phantom model consisting of four highly accurate steel rings (perfect reflectors) with diameters of 2, 3, 4 and 5 mm. Relative differences (unadjusted) of the phantom were respectively: 15.92, 13.01, 10.10 and 12.23%. After applying the adjustment: -0.96, -1.84, -1.35 and -1.43%. In vivo measurements were performed on 24 randomly selected ICUS studies. These showed differences for not adjusted vs. adjusted measurements of lumen-, vessel- and plaque volumes of -10.1 +/- 1.5, -6.7 +/- 0.9 and -4.4 +/- 0.6%. An off-line adjustment formula was derived and applied on previous numerical QCU output data showing relative differences for lumen- and vessel volumes of 0.36 +/- 0.51 and 0.13 +/- 0.31%. 30 MHz BSC catheters connected to a Clearview ultrasound console underestimate vessel dimensions. This can retrospectively be adjusted within QCU software as well as retrospectively on numerical QCU data using a mathematical model.
冠状动脉内超声（ICUS）常用于评估新介入技术的研究中。使用各种ICUS成像设备和材料进行的定量测量具有可比性非常重要。在评估定量冠状动脉超声（QCU）软件时，发现连接到Clearview超声控制台的波士顿科学公司（BSC）30 MHz导管显示的体外模型尺寸比预期的要小。与制造商合作确定了这种低估的原因，本文对此进行了描述，并对QCU软件进行了扩展调整。通过在由四个直径分别为2、3、4和5毫米的高精度钢环（完美反射体）组成的模型上进行体外测量来进行评估。模型的相对差异（未调整）分别为：15.92%、13.01%、10.10%和12.23%。应用调整后：-0.96%、-1.84%、-1.35%和-1.43%。对24项随机选择的ICUS研究进行了体内测量。结果显示，未调整测量与调整测量之间的管腔、血管和斑块体积差异分别为-10.1±1.5%、-6.7±0.9%和-4.4±0.6%。推导了一个离线调整公式，并将其应用于先前的QCU数值输出数据，结果显示管腔和血管体积的相对差异分别为0.36±0.51%和0.13±0.31%。连接到Clearview超声控制台的30 MHz BSC导管会低估血管尺寸。这可以在QCU软件中进行回顾性调整，也可以使用数学模型对QCU数值数据进行回顾性调整。
