白细胞介素受体相关激酶（IRAK-4）缺乏与细菌感染及无法维持抗体应答相关。
Interleukin receptor-associated kinase (IRAK-4) deficiency associated with bacterial infections and failure to sustain antibody responses.
作者信息
Day Noorbibi, Tangsinmankong Nutthapong, Ochs Hans, Rucker Rajivi, Picard Capucine, Casanova Jean-Laurent, Haraguchi Soichi, Good Robert
机构信息
Division of Allergy and Immunology, Department of Pediatrics, University of South Florida All Children's Hospital, Box 7070, 801 6th Street South, St Petersburg, FL 33701, USA.
出版信息
J Pediatr. 2004 Apr;144(4):524-6. doi: 10.1016/j.jpeds.2003.11.025.
We previously described a girl with recurrent episodes of pneumococcal pneumonia with septicemia and other infections,(1) found to have interleukin-1 receptor-associated kinase 4 deficiency (IRAK-4) deficiency.(2) In this report, we show that our patient is unable to sustain antibody responses either to polysaccharide or protein antigens or to a neoantigen-bacteriophage.
我们之前描述过一名患有复发性肺炎球菌肺炎伴败血症及其他感染的女孩，（1）发现其存在白细胞介素-1受体相关激酶4（IRAK-4）缺陷。（2）在本报告中，我们表明我们的患者无法对多糖或蛋白质抗原或新抗原噬菌体产生持续的抗体反应。
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