Nabili S, Kirkness C M
Tennent Institute of Ophthalmology, University of Glasgow, UK.
Eye (Lond). 2004 Apr;18(4):352-6. doi: 10.1038/sj.eye.6700644.
To assess efficacy of trans-scleral diode laser cyclophotocoagulation in the treatment of diabetic neovascular glaucoma refractory to medical therapy.
Case notes of 20 eyes of 20 patients who had the treatment were analysed. The mean follow-up after initial treatment was 22.5 months (range of 18-24).
Mean (SD) pretreatment intraocular pressure (IOP) for the 20 eyes was 34.4 mmHg (9.5) reducing to 18.2 mmHg (12.4) at the final index visit (P = 0.0001). The mean (SD) number of topical antiglaucoma medication was significantly lowered from 3.9 (0.3) to 1.2 (1.3). Four patients had visual acuity of 6/60 or better before the treatment. Two of them maintained the same level of vision and the other two had their vision reduced over the course of study; however, none of them deteriorated beyond 6/60. Six out of the remaining 16 patients who had vision of counting fingers or worse before treatment progressed to no perception of light at the final index visit. The mean (SD) number of treatment sessions was 1.45 (0.68). A total of 10 patients had previous pars plana vitrectomy (PPV). Patients with two or more PPVs developed hypotony (IOP </=5). There were five eyes with hypotony, one of which became phthisical.
Trans-scleral diode laser cyclophotocoagulation is a useful tool in the management of diabetic neovascular glaucoma. The current treatment regime needs to be adjusted to reflect higher risk of hypotony and phthisis in diabetic neovascular glaucoma in eyes that have had multiple pars plana vitrectomies.
评估经巩膜二极管激光睫状体光凝术治疗药物治疗无效的糖尿病性新生血管性青光眼的疗效。
分析20例接受该治疗的患者20只眼的病历记录。初始治疗后的平均随访时间为22.5个月(范围18 - 24个月)。
20只眼治疗前平均(标准差)眼压为34.4 mmHg(9.5),在最后一次随访时降至18.2 mmHg(12.4)(P = 0.0001)。局部抗青光眼药物的平均(标准差)使用数量从3.9(0.3)显著降至1.2(1.3)。4例患者在治疗前视力为6/60或更好。其中2例维持相同视力水平,另外2例在研究过程中视力下降;然而,他们的视力均未恶化至低于6/60。其余16例治疗前视力为指数计数或更差的患者中,6例在最后一次随访时进展为无光感。平均(标准差)治疗次数为1.45(0.68)。共有10例患者曾接受过玻璃体切割术(PPV)。接受过两次或更多次PPV的患者发生低眼压(眼压≤5)。有5只眼出现低眼压,其中1只眼眼球萎缩。
经巩膜二极管激光睫状体光凝术是治疗糖尿病性新生血管性青光眼的一种有效方法。目前的治疗方案需要调整,以反映在接受过多次玻璃体切割术的糖尿病性新生血管性青光眼中发生低眼压和眼球萎缩的较高风险。