Klevay L M, Christopherson D M, Shuler T R
United States Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, ND 58202-9034, USA.
Eur J Clin Nutr. 2004 Oct;58(10):1359-64. doi: 10.1038/sj.ejcn.1601975.
Hair mineral analyses are being performed frequently both with and without medical advice. Reasons for analysis often are ill defined.
To assess variability of trace element data both within a series of samples from an individual and among mean values published from other research laboratories.
Many samples of hair were collected carefully from a healthy man over a comparatively long period of time and were processed and analyzed under standard conditions. Extensive published data from other research laboratories also were reviewed and compared.
Coefficients of variation for trace elements in hair of the donor ranged from 17 to 74% for the essential elements copper, selenium and zinc and from 53 to 121% for the potential intoxicants aluminum, cadmium and lead. The ratio of high mean to low mean for values published by others on hair samples from healthy people ranged from two for selenium and zinc to 18 for aluminum.
Hair analysis should be based on a diagnostic hypothesis such as cadmium intoxication or copper deficiency rather than on the ease of analysis or attempts to explain vague symptoms because within-person variability is large and interlaboratory agreement on normal values is poor.
无论有无医学建议，毛发矿物质分析都在频繁进行。分析的原因往往界定不清。
评估个体一系列样本中微量元素数据的变异性以及其他研究实验室公布的均值之间的变异性。
在较长时间内从一名健康男性身上仔细采集了许多毛发样本，并在标准条件下进行处理和分析。还对其他研究实验室广泛公布的数据进行了审查和比较。
供体毛发中必需元素铜、硒和锌的微量元素变异系数在17%至74%之间，潜在中毒元素铝、镉和铅的变异系数在53%至121%之间。其他人公布的健康人毛发样本值的高均值与低均值之比，硒和锌为2，铝为18。
毛发分析应基于镉中毒或铜缺乏等诊断假设，而不是基于分析的便利性或试图解释模糊症状，因为个体内部变异性大，实验室间关于正常值的一致性差。
