• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Gastro-electric dysrhythm and lack of gastric interstitial cells of cajal.胃肠电节律紊乱与胃Cajal间质细胞缺失
World J Gastroenterol. 2004 Apr 15;10(8):1227-30. doi: 10.3748/wjg.v10.i8.1227.
2
Loss of intramuscular and submuscular interstitial cells of Cajal and associated enteric nerves is related to decreased gastric emptying in streptozotocin-induced diabetes.链脲佐菌素诱导的糖尿病中，肌内和肌间 Cajal 间质细胞及相关肠神经的丧失与胃排空减少有关。
Neurogastroenterol Motil. 2009 Oct;21(10):1095-e92. doi: 10.1111/j.1365-2982.2009.01336.x. Epub 2009 Jun 30.
3
Long-pulse gastric electrical stimulation protects interstitial cells of Cajal in diabetic rats via IGF-1 signaling pathway.长脉冲胃电刺激通过胰岛素样生长因子-1信号通路保护糖尿病大鼠的Cajal间质细胞。
World J Gastroenterol. 2016 Jun 21;22(23):5353-63. doi: 10.3748/wjg.v22.i23.5353.
4
[Changes of ultrastructure characteritics of Cajal interstitial cell in intestinal tract of diabetic rats].
Zhonghua Nei Ke Za Zhi. 2002 May;41(5):310-2.
5
Electroacupuncture at ST36 increases contraction of the gastric antrum and improves the SCF/c-kit pathway in diabetic rats.电针对 ST36 穴位的刺激可增强胃窦收缩，并改善糖尿病大鼠的 SCF/c-kit 通路。
Am J Chin Med. 2013;41(6):1233-49. doi: 10.1142/S0192415X13500833.
6
Enteric motor neurons form synaptic-like junctions with interstitial cells of Cajal in the canine gastric antrum.肠运动神经元与犬胃窦部的 Cajal 间质细胞形成类似突触的连接。
Cell Tissue Res. 2003 Mar;311(3):299-313. doi: 10.1007/s00441-002-0657-1. Epub 2003 Feb 25.
7
Neural regulation of slow-wave frequency in the murine gastric antrum.小鼠胃窦部慢波频率的神经调节
Am J Physiol Gastrointest Liver Physiol. 2006 Mar;290(3):G486-95. doi: 10.1152/ajpgi.00349.2005. Epub 2005 Sep 15.
8
The Effects of Auricular Electro-Acupuncture on Ameliorating the Dysfunction of Interstitial Cells of Cajal Networks and nNOSmRNA Expression in Antrum of STZ-Induced Diabetic Rats.耳穴电针对改善链脲佐菌素诱导的糖尿病大鼠胃窦Cajal间质细胞网络功能障碍及nNOSmRNA表达的影响
PLoS One. 2016 Dec 8;11(12):e0166638. doi: 10.1371/journal.pone.0166638. eCollection 2016.
9
Electroacupuncture at ST36 ameliorates gastric emptying and rescues networks of interstitial cells of Cajal in the stomach of diabetic rats.电针足三里可改善糖尿病大鼠胃排空并挽救胃中 Cajal 间质细胞网络。
PLoS One. 2013 Dec 31;8(12):e83904. doi: 10.1371/journal.pone.0083904. eCollection 2013.
10
[Effects of Electroacupuncture on Ultrastructure of Interstitial Cells of Cajal and Stem Cell Factor-kit Signal Pathway of Gastric Antrum in Diabetic Gastroparesis Rats].[电针对糖尿病胃轻瘫大鼠胃窦Cajal间质细胞超微结构及干细胞因子- c-kit信号通路的影响]
Zhen Ci Yan Jiu. 2017 Dec 25;42(6):482-8. doi: 10.13702/j.1000-0607.2017.06.003.

引用本文的文献

1
Unmasking Gastroparesis in Diabetes During Ramadan: Challenges and Management Strategies.斋月期间糖尿病性胃轻瘫的隐匿性：挑战与管理策略
J Clin Med. 2025 Mar 15;14(6):1997. doi: 10.3390/jcm14061997.
2
Mild diabetes: long-term effects on gastric motility evaluated in rats.轻度糖尿病：在大鼠中评估对胃动力的长期影响。
Int J Exp Pathol. 2018 Feb;99(1):29-37. doi: 10.1111/iep.12262. Epub 2018 Feb 26.
3
Diabetic and idiopathic gastroparesis is associated with loss of CD206-positive macrophages in the gastric antrum.糖尿病性和特发性胃轻瘫与胃窦中CD206阳性巨噬细胞的缺失有关。
Neurogastroenterol Motil. 2017 Jun;29(6). doi: 10.1111/nmo.13018. Epub 2017 Jan 9.
4
Effect of electroacupuncture on gastric interstitial cells of Cajal in a rat model of diabetic gastroparesis.电针对糖尿病胃轻瘫大鼠模型中Cajal间质细胞的影响
Exp Ther Med. 2016 Jun;11(6):2489-2494. doi: 10.3892/etm.2016.3185. Epub 2016 Mar 24.
5
Is Interstitial Cells of Cajal‒opathy Present in Gastroparesis?胃轻瘫中是否存在 Cajal 间质细胞病变？
J Neurogastroenterol Motil. 2015 Oct 1;21(4):486-93. doi: 10.5056/jnm15075.
6
Connexin and pannexin signaling in gastrointestinal and liver disease.连接蛋白和泛连接蛋白信号传导在胃肠道和肝脏疾病中的作用
Transl Res. 2015 Oct;166(4):332-43. doi: 10.1016/j.trsl.2015.05.005. Epub 2015 May 16.
7
Alterations of colonic contractility in an interleukin-10 knockout mouse model of inflammatory bowel disease.白细胞介素-10基因敲除小鼠炎症性肠病模型中结肠收缩性的改变
J Neurogastroenterol Motil. 2015 Jan 1;21(1):51-61. doi: 10.5056/jnm14008.
8
Diabetic gastrointestinal motility disorders and the role of enteric nervous system: current status and future directions.糖尿病性胃肠动力障碍与肠神经系统的作用：现状与未来方向
Neurogastroenterol Motil. 2014 May;26(5):611-24. doi: 10.1111/nmo.12330. Epub 2014 Mar 24.
9
Disruption of interstitial cells of Cajal networks after massive small bowel resection.巨大小肠切除术后 Cajal 间质细胞网络的破坏。
World J Gastroenterol. 2013 Jun 14;19(22):3415-22. doi: 10.3748/wjg.v19.i22.3415.
10
Alterations of colonic contractility in long-term diabetic rat model.长期糖尿病大鼠模型中结肠收缩性的改变。
J Neurogastroenterol Motil. 2011 Oct;17(4):372-80. doi: 10.5056/jnm.2011.17.4.372. Epub 2011 Oct 31.

本文引用的文献

1
Enteric motor neurons form synaptic-like junctions with interstitial cells of Cajal in the canine gastric antrum.肠运动神经元与犬胃窦部的 Cajal 间质细胞形成类似突触的连接。
Cell Tissue Res. 2003 Mar;311(3):299-313. doi: 10.1007/s00441-002-0657-1. Epub 2003 Feb 25.
2
Role of interstitial cells of Cajal in motility disorders of the bowel.Cajal间质细胞在肠道运动障碍中的作用。
Am J Gastroenterol. 2003 Mar;98(3):618-24. doi: 10.1111/j.1572-0241.2003.07295.x.
3
Involvement of intramuscular interstitial cells in nitrergic inhibition in the mouse gastric antrum.小鼠胃窦部肌内间质细胞参与一氧化氮能抑制作用
J Physiol. 2003 Feb 1;546(Pt 3):751-63. doi: 10.1113/jphysiol.2002.033365.
4
Widespread changes in neurotransmitter expression and number of enteric neurons and interstitial cells of Cajal in lethal spotted mice: an explanation for persisting dysmotility after operation for Hirschsprung's disease?致死斑点小鼠中神经递质表达、肠神经元数量及 Cajal 间质细胞的广泛变化：先天性巨结肠症手术后持续存在的运动障碍的一种解释？
Dig Dis Sci. 2002 May;47(5):1049-64. doi: 10.1023/a:1015085923245.
5
The evaluation of gastrointestinal function in diabetic patients.糖尿病患者胃肠功能的评估。
World J Gastroenterol. 1999 Aug;5(4):277-282. doi: 10.3748/wjg.v5.i4.277.
6
Do gap junctions couple interstitial cells of Cajal pacing and neurotransmission to gastrointestinal smooth muscle?
Neurogastroenterol Motil. 2001 Aug;13(4):297-307. doi: 10.1046/j.1365-2982.2001.00269.x.
7
Pivotal role of the interstitial cells of Cajal in the nitric oxide signaling pathway of rat small intestine. Morphological evidence.大鼠小肠中Cajal间质细胞在一氧化氮信号通路中的关键作用。形态学证据。
Cell Tissue Res. 2001 Sep;305(3):331-40. doi: 10.1007/s004410100410.
8
A reduction in interstitial cells of Cajal in horses with equine dysautonomia (grass sickness).患有马自主神经失调症（青草搐搦症）的马匹中Cajal间质细胞数量减少。
Auton Neurosci. 2001 Sep 17;92(1-2):37-44. doi: 10.1016/S1566-0702(01)00316-2.
9
Loss of interstitial cells of cajal and inhibitory innervation in insulin-dependent diabetes.胰岛素依赖型糖尿病中Cajal间质细胞的缺失及抑制性神经支配的丧失
Gastroenterology. 2001 Aug;121(2):427-34. doi: 10.1053/gast.2001.26264.
10
Selective knockout of intramuscular interstitial cells reveals their role in the generation of slow waves in mouse stomach.选择性敲除肌内间质细胞揭示其在小鼠胃慢波产生中的作用。
J Physiol. 2001 Mar 15;531(Pt 3):827-33. doi: 10.1111/j.1469-7793.2001.0827h.x.

胃肠电节律紊乱与胃Cajal间质细胞缺失

Gastro-electric dysrhythm and lack of gastric interstitial cells of cajal.

作者信息

Long Qing-Lin, Fang Dian-Chun, Shi Hong-Tao, Luo Yuan-Hui

机构信息

Gastroenterology Research Center, South-west Hospital, Third Military Medical Univisity, Chongqing 40038, China.

出版信息

World J Gastroenterol. 2004 Apr 15;10(8):1227-30. doi: 10.3748/wjg.v10.i8.1227.

DOI:10.3748/wjg.v10.i8.1227
PMID:15069732
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4656367/
Abstract

AIM

The pathophysiology underlying gastrointestinal complications of long-standing diabetes is poorly understood. Recent evidence suggests an important role of intestitial cells of cajal in controlling gastrointestinal motility. The aim of this study was to clarify the changes of ultrastructural characteristics of interstitial cells of cajal in stomach of diabetic gastro-electric dysrhythmic rats.

METHODS

Rats were randomly divided into diabetic group and control group, the model of diabetic rats was established by peritoneally injection of streptozotocin. Electrogastrograms were recorded and intestitial cells of cajal in antrum were observed by electrictelescopy after diabetic model rat was established for 3 mo.

RESULTS

In the rats of diabetic group, the gastro-electric dysrhythmia was increased compared with control group, the abnormal rhythm index and the cofficient of variation of slow wave frequency were significantly higher than those of normal rats. The number of the gap junctions of interstitial cells of cajal in antrum of diabetic rats was significantly decreased, and the remaining structures were damaged. The organelles were also damaged, and vacuoles were formed.

CONCLUSION

It is possible that changes in ultrastructural characteristics of interstitial cells of cajal in stomach are one of the mechanisms underlying gastro-electric dysrhythm in diabetic rats.

摘要

目的

长期糖尿病胃肠并发症的病理生理学机制尚不清楚。最近的证据表明， Cajal间质细胞在控制胃肠动力方面发挥重要作用。本研究旨在阐明糖尿病胃电节律失常大鼠胃中Cajal间质细胞超微结构特征的变化。

方法

将大鼠随机分为糖尿病组和对照组，通过腹腔注射链脲佐菌素建立糖尿病大鼠模型。造模3个月后，记录胃电图并用电镜观察胃窦Cajal间质细胞。

结果

糖尿病组大鼠胃电节律失常较对照组增多，异常节律指数和慢波频率变异系数显著高于正常大鼠。糖尿病大鼠胃窦Cajal间质细胞缝隙连接数量显著减少，其余结构受损。细胞器也受损并形成空泡。

结论

胃中Cajal间质细胞超微结构特征的变化可能是糖尿病大鼠胃电节律失常的机制之一。