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胃肠电节律紊乱与胃Cajal间质细胞缺失

Gastro-electric dysrhythm and lack of gastric interstitial cells of cajal.

作者信息

Long Qing-Lin, Fang Dian-Chun, Shi Hong-Tao, Luo Yuan-Hui

机构信息

Gastroenterology Research Center, South-west Hospital, Third Military Medical Univisity, Chongqing 40038, China.

出版信息

World J Gastroenterol. 2004 Apr 15;10(8):1227-30. doi: 10.3748/wjg.v10.i8.1227.

DOI:10.3748/wjg.v10.i8.1227
PMID:15069732
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4656367/
Abstract

AIM

The pathophysiology underlying gastrointestinal complications of long-standing diabetes is poorly understood. Recent evidence suggests an important role of intestitial cells of cajal in controlling gastrointestinal motility. The aim of this study was to clarify the changes of ultrastructural characteristics of interstitial cells of cajal in stomach of diabetic gastro-electric dysrhythmic rats.

METHODS

Rats were randomly divided into diabetic group and control group, the model of diabetic rats was established by peritoneally injection of streptozotocin. Electrogastrograms were recorded and intestitial cells of cajal in antrum were observed by electrictelescopy after diabetic model rat was established for 3 mo.

RESULTS

In the rats of diabetic group, the gastro-electric dysrhythmia was increased compared with control group, the abnormal rhythm index and the cofficient of variation of slow wave frequency were significantly higher than those of normal rats. The number of the gap junctions of interstitial cells of cajal in antrum of diabetic rats was significantly decreased, and the remaining structures were damaged. The organelles were also damaged, and vacuoles were formed.

CONCLUSION

It is possible that changes in ultrastructural characteristics of interstitial cells of cajal in stomach are one of the mechanisms underlying gastro-electric dysrhythm in diabetic rats.

摘要

目的

长期糖尿病胃肠并发症的病理生理学机制尚不清楚。最近的证据表明， Cajal间质细胞在控制胃肠动力方面发挥重要作用。本研究旨在阐明糖尿病胃电节律失常大鼠胃中Cajal间质细胞超微结构特征的变化。

方法

将大鼠随机分为糖尿病组和对照组，通过腹腔注射链脲佐菌素建立糖尿病大鼠模型。造模3个月后，记录胃电图并用电镜观察胃窦Cajal间质细胞。

结果

糖尿病组大鼠胃电节律失常较对照组增多，异常节律指数和慢波频率变异系数显著高于正常大鼠。糖尿病大鼠胃窦Cajal间质细胞缝隙连接数量显著减少，其余结构受损。细胞器也受损并形成空泡。

结论

胃中Cajal间质细胞超微结构特征的变化可能是糖尿病大鼠胃电节律失常的机制之一。

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