García-Albea E, Pérez Trullen J M
Department of Neurology, University Hospital Príncipe de Asturias, Alcalá University, Alcalá de Henares, Madrid, Spain.
J Hist Neurosci. 2003 Dec;12(4):437-45. doi: 10.1076/jhin.12.4.437.27919.
The object of this review is to recapitulate historical events tied to the discovery of Alzheimer's disease and to narrate the contribution by two graduates of the Spanish School of Neurology, N. Achúcarro and G. Lafora, who went on to describe the first cases in North America. Both Achúcarro and Lafora had studied with Alois Alzheimer at his Nervenklinik in Munich, Germany. Subsequently, their scientific skills were put to work at the neuropathology laboratory at the Government Hospital for the Insane in Washington, D.C. Achúcarro described the first American case of this disease in a 77-year-old patients in 1910. All the descriptions were accompanied by new findings, such as granular degeneration. This was the sixth case recorded in the literature worldwide. One year later, in 1911, Lafora presented a third case, a 62-year-old Civil War veteran, and subsequently a fifth case, a 50-year-old woman, in 1914. In this case Lafora observed histological structures similar to Lewy bodies. These original contributions have not been sufficiently mentioned in writings dealing with the history of Alzheimer's disease.
本综述的目的是概括与阿尔茨海默病发现相关的历史事件，并讲述西班牙神经学派的两位毕业生N. 阿楚卡罗和G. 拉福拉的贡献，他们后来在北美描述了首例病例。阿楚卡罗和拉福拉都曾在德国慕尼黑的阿洛伊斯·阿尔茨海默的神经科诊所跟随他学习。随后，他们的科学技能在华盛顿特区政府精神病医院的神经病理学实验室得到施展。1910年，阿楚卡罗在一名77岁患者身上描述了美国首例这种疾病。所有描述都伴随着新发现，如颗粒变性。这是全球文献中记录的第六例。一年后的1911年，拉福拉报告了第三例，一名62岁的内战退伍军人，随后在1914年报告了第五例，一名50岁女性。在这个病例中，拉福拉观察到了类似于路易小体的组织学结构。这些原创性贡献在关于阿尔茨海默病历史的著作中并未得到充分提及。
