Servatius Richard J, Beck Kevin D
Department of Veterans Affairs, New Jersey Health Care System, East Orange, New Jersey 07019, USA.
Integr Physiol Behav Sci. 2003 Jul-Sep;38(3):169-78. doi: 10.1007/BF02688851.
Exposure to inescapable stressors enhances cue-dependent learning in male rats; enhanced learning is apparent as facilitated acquisition of the classically conditioned eyeblink respouse (CCER). The proinflammatory cytokines, in particular interleukin (IL)-1beta, are presumed to orchestrate a number of acute-phase stress responses in rats, most notably fever, reduced feeding, and inactivity. Little is known of the impact proinflammatory cytokines have on learning and memory processes. Here, we address the effects of IL-1beta treatment on acquisition of the classically conditioned eyeblink response 2 hours [?] after injection in male rats. Training was accomplished with a delay-type paradigm (500-ms conditional stimulus coterminating with a 10-ms periorbital unconditional stimulation). Facilitated acquisition was clearly apparent in rats treated with IL-1beta (3.0 microg/kg). In a second experiment, we compared rats treated with 3.0 microg/kg to those treated with 1.0 microg/kg. Facilitated acquisition was reproduced, but the lower dose did not appreciably affect acquisition. These data further support contentions that IL-1beta has anxiogenic properties, affecting basic new motor learning in a manner similar to that observed after exposure to stress.
暴露于不可逃避的应激源会增强雄性大鼠的线索依赖性学习；这种增强的学习表现为经典条件性眨眼反应（CCER）的习得得到促进。促炎细胞因子，特别是白细胞介素（IL）-1β，被认为在大鼠中协调多种急性期应激反应，最显著的是发热、进食减少和活动减少。关于促炎细胞因子对学习和记忆过程的影响知之甚少。在此，我们探讨了注射IL-1β两小时后对雄性大鼠经典条件性眨眼反应习得的影响。训练采用延迟型范式（500毫秒条件刺激与10毫秒眶周非条件刺激同时终止）。在接受IL-1β（3.0微克/千克）治疗的大鼠中，习得促进明显。在第二个实验中，我们将接受3.0微克/千克治疗的大鼠与接受1.0微克/千克治疗的大鼠进行比较。再次出现了习得促进，但较低剂量对习得没有明显影响。这些数据进一步支持了IL-1β具有致焦虑特性的观点，它以类似于暴露于应激后观察到的方式影响基本的新运动学习。
