Doucet Eric, Pomerleau Marjorie, Harper Mary-Ellen
School of Human Kinetics, and Department of Biochemistry, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5.
J Clin Endocrinol Metab. 2004 Apr;89(4):1727-32. doi: 10.1210/jc.2003-031459.
Adaptations that promote positive energy balance appear in response to dietary restriction. The aim of this study was to determine whether fasting and postprandial total ghrelin increase in response to short-term energy restriction. Fifteen adult male subjects were subjected to a 4-d energy restricted diet (-800 kcal/d). Body weight and composition, resting energy expenditure, respiratory quotient, fasting and postprandial appetite scores, and fasting and postprandial serum leptin and total ghrelin were determined before and after dietary intervention. Despite the fact that fat mass remained unchanged after the 4 d, fasting (-36%; P </= 0.01) and postprandial serum leptin (-27%; P = 0.01) were significantly reduced. A significant reduction in total ghrelin was observed after the meal (P </= 0.05); however, fasting and postprandial total ghrelin remained unchanged at the end of the intervention. Although leptin was a significant correlate of appetite before and after the intervention, no such associations were noted for total ghrelin. Finally, a significant relation between total ghrelin and respiratory quotient was noted at the onset of the diet (r = 0.63; P </= 0.01). Fasting and postprandial total ghrelin levels remain unchanged after short-term energy restriction despite a significant fall in leptin.
促进正能量平衡的适应性变化似乎是对饮食限制的反应。本研究的目的是确定短期能量限制后空腹和餐后总胃饥饿素是否会增加。15名成年男性受试者接受了为期4天的能量限制饮食（-800千卡/天）。在饮食干预前后测定体重和身体组成、静息能量消耗、呼吸商、空腹和餐后食欲评分以及空腹和餐后血清瘦素和总胃饥饿素。尽管4天后脂肪量保持不变，但空腹血清瘦素（-36%；P≤0.01）和餐后血清瘦素（-27%；P = 0.01）显著降低。餐后观察到总胃饥饿素显著降低（P≤0.05）；然而，干预结束时空腹和餐后总胃饥饿素保持不变。尽管干预前后瘦素与食欲显著相关，但总胃饥饿素未发现此类关联。最后，在饮食开始时发现总胃饥饿素与呼吸商之间存在显著关系（r = 0.63；P≤0.01）。尽管瘦素显著下降，但短期能量限制后空腹和餐后总胃饥饿素水平保持不变。
