Cunningham Anthony L, Dwyer Dominic E
Centre for Virus Research, Westmead Millennium Institute and Westmead Hospital, University of Sydney, Westmead, New South Wales, Australia.
J HIV Ther. 2004 Feb;9(1):9-13.
An elucidation of the mechanisms of herpes simplex virus type 2 (HSV-2)/HIV co-infection, including studies of the immunohistochemistry of co-infected lesions, co-infection of dendritic cells, confirmation and/or determination of the mechanism of keratinocyte co-infection, should allow targeting with specific interventions, such as the tailoring of microbicides, to HSV-2/HIV co-infection rather than to HIV infection alone. This could be especially important in countries where the HSV seroprevalence is very high, for example in Central Africa, where HSV-2 may stimulate HIV transmission in more than 40% of cases.
阐明2型单纯疱疹病毒（HSV-2）/HIV合并感染的机制，包括对合并感染病变的免疫组织化学研究、树突状细胞的合并感染、角质形成细胞合并感染机制的确认和/或确定，应能实现针对HSV-2/HIV合并感染而非仅针对HIV感染进行特定干预，如定制杀微生物剂。这在HSV血清流行率非常高的国家可能尤为重要，例如在中非，HSV-2可能在超过40%的病例中促进HIV传播。
