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在一个种族多样化的HIV-1感染者队列中，HIV-1诊断时的2型单纯疱疹病毒（HSV-2）血清流行率以及HIV-1诊断后的血清发病率。

Herpes simplex virus type 2 (HSV-2) seroprevalence at the time of HIV-1 diagnosis and seroincidence after HIV-1 diagnosis in an ethnically diverse cohort of HIV-1-infected persons.

作者信息

Ramaswamy Meghna, Sabin Caroline, McDonald Candice, Smith Melvyn, Taylor Chris, Geretti Anna Maria

机构信息

Department of Virology, Royal Free and University College Medical School, London, UK.

出版信息

Sex Transm Dis. 2006 Feb;33(2):96-101. doi: 10.1097/01.olq.0000187211.61052.c7.

DOI:10.1097/01.olq.0000187211.61052.c7

PMID:16432480

Abstract

OBJECTIVE

The objective of this study was to determine herpes simplex virus type 2 (HSV-2) seroprevalence at HIV-1 diagnosis and seroincidence > or =1 year after HIV-1 diagnosis.

METHODS

HSV type-specific antibodies were detected by enzyme immunoassay.

RESULTS

The cohort comprised 850 adults diagnosed HIV-positive in 1986-2001 and followed for a median of 3 years. HSV-2 seroprevalence was 63% (95% confidence interval [CI], 60-66%) and was associated with female gender, heterosexual risk group, black ethnicity, and older age. HSV-2 seroincidence was 1.8 per 100 person-years (95% CI, 0.8-2.8) and was associated with other sexually transmitted diseases, including human papilloma virus infection (P = 0.005) and gonorrhea (P = 0.05). A diagnosis of genital herpes was made in 21% HSV-2-seropositive persons and was more likely in those who tested HIV-positive before 1997 (adjusted odds ratio, 5.11; 95% CI, 3.28-7.98; P = 0.0001).

CONCLUSIONS

Results confirm the epidemiologic association between HIV-1 and HSV-2. HSV-2 seroconversion was a marker of high-risk sexual behavior. The likelihood of developing symptoms of genital herpes declined from 1997 onward.

摘要

目的

本研究的目的是确定在人类免疫缺陷病毒1型（HIV-1）诊断时2型单纯疱疹病毒（HSV-2）的血清流行率以及在HIV-1诊断后≥1年的血清发病率。

方法

采用酶免疫法检测HSV型特异性抗体。

结果

该队列包括1986年至2001年诊断为HIV阳性的850名成年人，中位随访时间为3年。HSV-2血清流行率为63%（95%置信区间[CI]，60-66%），与女性性别、异性恋风险组、黑人种族和年龄较大有关。HSV-2血清发病率为每100人年1.8例（95%CI，0.8-2.8），与其他性传播疾病有关，包括人乳头瘤病毒感染（P = 0.005）和淋病（P = 0.05）。21%的HSV-2血清阳性者被诊断为生殖器疱疹，1997年之前检测HIV阳性的人更易患生殖器疱疹（校正优势比，5.11；95%CI，3.28-7.98；P = 0.0001）。