Rowe B H, Edmonds M L, Spooner C H, Diner B, Camargo C A
Division Emergency Medicine, University of Alberta, 1G1.43 Walter Mackenzie Centre, 8440-112 Street, Edmonton, Alberta, Canada T6G 287.
Respir Med. 2004 Apr;98(4):275-84. doi: 10.1016/j.rmed.2003.11.016.
Asthma is a chronic inflammatory disease, which is characterised by reversible airflow obstruction in response to a variety of stimuli. Exacerbations in response to airway irritants are part of the natural history of asthma, but often they also represent a failure in chronic treatment. Presentations to emergency departments and other acute care settings are common and frequently lead to hospitalisation and other complications. After treatment, however, most patients are discharged to the care of their primary care physician for further management. This review highlights the role of systemic and inhaled corticosteroids as mainstays of treatment in the acute and sub-acute phase of an exacerbation. These agents form the basis of most current clinical practice guidelines, yet their use is not universal. We will review the evidence for the use of these agents that arises from the Cochrane Collaboration of Systematic Reviews contained in the Cochrane Library.
哮喘是一种慢性炎症性疾病，其特征是对多种刺激产生可逆性气流阻塞。气道刺激物引发的病情加重是哮喘自然病程的一部分，但它们往往也意味着慢性治疗的失败。在急诊科和其他急性护理机构就诊很常见，且常常导致住院及其他并发症。然而，经过治疗后，大多数患者会出院并由其初级保健医生继续进行管理。本综述强调了全身用和吸入性糖皮质激素在病情加重的急性和亚急性期作为主要治疗药物的作用。这些药物构成了当前大多数临床实践指南的基础，但其使用并不普遍。我们将回顾《考克兰图书馆》中考克兰系统评价协作网关于这些药物使用的证据。
