Heshmat M Y, Kovi J, Rao M S, Mohla S, Spurlin D W, Jean-Baptiste G
Department of Community Health and Family Practice, Howard University College of Medicine, Washington, DC 20059.
J Natl Med Assoc. 1992 Aug;84(8):677-80.
This article reports the results of a pathoepidemiological study of a cohort of black men who had prostatic surgery at Howard University Hospital between 1968 and 1989. The median age of patients at diagnosis of prostate cancer increased by 8 years during the study period, indicating either a delay in seeking medical care or a true delay in onset of the disease. The trends of prevalence of biopsies with cancer in various age groups suggested a sharp rise in the incidence of prostate cancer after the age of 70. The significant increase in popularity of needle biopsy during the period 1982 to 1989 after a 7-year plateau is an indication of increased perceived value of this procedure with experience and technical improvement. The prevalence of biopsies with cancer in all successive time periods of the study showed a bimodal distribution with an early hump in the 50- to 54-year-old age group. This hump is analogous to the break in the rising incidence of breast cancer between the ages of 47 and 52 (Clemmesen hook). This similarity could be explained on the basis of hormonal dependence of the two cancers.
本文报道了一项对1968年至1989年间在霍华德大学医院接受前列腺手术的一群黑人男性进行的病理流行病学研究结果。在研究期间，前列腺癌诊断时患者的中位年龄增加了8岁，这表明要么是就医延迟，要么是疾病真正的发病延迟。各年龄组癌症活检患病率趋势表明，70岁以后前列腺癌发病率急剧上升。在经历7年平稳期后，1982年至1989年期间针吸活检的普及程度显著增加，这表明随着经验积累和技术改进，该检查方法的价值得到了更高认可。研究所有连续时间段内癌症活检的患病率呈双峰分布，在50至54岁年龄组出现早期高峰。这个高峰类似于47至52岁之间乳腺癌发病率上升趋势中的断点（克莱姆森曲线）。这种相似性可以基于两种癌症的激素依赖性来解释。
