Kovi J, Mostofi F K, Heshmat M Y, Enterline J P
Department of Pathology, Howard University College of Medicine, Washington, D.C. 20059.
Cancer. 1988 Feb 1;61(3):555-61. doi: 10.1002/1097-0142(19880201)61:3<555::aid-cncr2820610322>3.0.co;2-h.
Step-sections of 429 whole prostate glands were studied. Large acinar atypical hyperplasia was graded as mild, moderate, and severe based on the degree of cellular anaplasia. The relationship between atypical hyperplasia and prostatic carcinoma was investigated. There was a strong association between prevalence and grade of atypical hyperplasia and prostatic carcinoma in patients up to 60 years old. Beyond the age of 60 no association was detected. In the younger age groups (36 to 60 years) atypical hyperplasia was found in 86.8% of prostates with carcinoma, but only in 37.9% of benign glands. Corresponding figures for the over-60 age group were 68.8% and 65.1%, respectively. A biologic explanation of the association between atypical hyperplasia and carcinoma in the younger age groups has been proposed. It was suggested that these men with atypical hyperplasia, particularly with severe atypical hyperplasia, have a greater risk for developing prostatic carcinoma.
对429个完整前列腺进行了连续切片研究。根据细胞间变程度，将大腺泡非典型增生分为轻度、中度和重度。研究了非典型增生与前列腺癌之间的关系。在60岁及以下的患者中，非典型增生的患病率和分级与前列腺癌之间存在密切关联。60岁以上未检测到关联。在较年轻的年龄组（36至60岁）中，86.8%患有癌的前列腺中发现了非典型增生，但良性腺体中仅为37.9%。60岁以上年龄组的相应数字分别为68.8%和65.1%。已对较年轻年龄组中非典型增生与癌之间的关联提出了生物学解释。有人提出，这些患有非典型增生，尤其是重度非典型增生的男性患前列腺癌的风险更大。
